Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice.
J Neurosci
; 41(24): 5315-5329, 2021 06 16.
Article
en En
| MEDLINE
| ID: mdl-33980545
ABSTRACT
Impairment of episodic memory, a class of memory for spatiotemporal context of an event, is an early symptom of Alzheimer's disease. Both spatial and temporal information are encoded and represented in the hippocampal neurons, but how these representations are impaired under amyloid ß (Aß) pathology remains elusive. We performed chronic imaging of the hippocampus in awake male amyloid precursor protein (App) knock-in mice behaving in a virtual reality environment to simultaneously monitor spatiotemporal representations and the progression of Aß depositions. We found that temporal representation is preserved, whereas spatial representation is significantly impaired in the App knock-in mice. This is because of the overall reduction of active place cells, but not time cells, and compensatory hyperactivation of remaining place cells near Aß aggregates. These results indicate the differential impact of Aß aggregates on two major modalities of episodic memory, suggesting different mechanisms for forming and maintaining these two representations in the hippocampus.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Región CA1 Hipocampal
/
Enfermedad de Alzheimer
/
Trastornos de la Memoria
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
J Neurosci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Japón