Cu(I)-Catalyzed asymmetric <i>exo</i>-selective synthesis of substituted pyrrolidines <i>via</i> a 1,3-dipolar cycloaddition reaction.

Biswas, Rayhan G; Ray, Sumit K; Kannaujiya, Vinod K; Unhale, Rajshekhar A; Singh, Vinod K

Cu(I)-Catalyzed asymmetric exo-selective synthesis of substituted pyrrolidines via a 1,3-dipolar cycloaddition reaction.

Biswas, Rayhan G; Ray, Sumit K; Kannaujiya, Vinod K; Unhale, Rajshekhar A; Singh, Vinod K.

Afiliación

Biswas RG; Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal, Madhya Pradesh 462 066, India.
Ray SK; Department of Chemistry, Kharagpur College, Paschim Medinipur, West Bengal 721305, India.
Kannaujiya VK; Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal, Madhya Pradesh 462 066, India.
Unhale RA; Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal, Madhya Pradesh 462 066, India.
Singh VK; Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208 016, India. vinodks@iitk.ac.in.

Org Biomol Chem ; 19(21): 4685-4690, 2021 06 02.

Article en En | MEDLINE | ID: mdl-33982725

RESUMEN

An (R)-DM-BINAP/Cu(CH3CN)4BF4 complex catalyzed exo-selective asymmetric 1,3-dipolar cycloaddition (1,3-DCA) reaction of imino esters with α,ß-unsaturated pyrazoleamides has been developed. A series of highly functionalized pyrrolidines with multiple stereogenic centers were obtained with good yields and diastereoselectivities and excellent enantioselectivities (up to 99% ee).

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

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