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Facile one-pot synthesis of diarylacetylenes from arylaldehydes via an addition-double elimination process.
Chen, Jianyang; Zhang, Xuan; Wu, Jiajun; Wang, Rui; Lei, Chunlin; An, Yanan.
Afiliación
  • Chen J; Chongqing Key Laboratory of Environmental Materials & Remediation Technologies, College of Chemistry and Environmental Engineering, Chongqing University of Arts and Sciences, Yongchuan 402160, China. catalystchen@126.com.
  • Zhang X; School of Intelligent Manufacturing Engineering, Chongqing University of Arts and Sciences, Yongchuan 402160, China.
  • Wu J; Chongqing Key Laboratory of Environmental Materials & Remediation Technologies, College of Chemistry and Environmental Engineering, Chongqing University of Arts and Sciences, Yongchuan 402160, China. catalystchen@126.com.
  • Wang R; Chongqing Key Laboratory of Environmental Materials & Remediation Technologies, College of Chemistry and Environmental Engineering, Chongqing University of Arts and Sciences, Yongchuan 402160, China. catalystchen@126.com.
  • Lei C; Chongqing Key Laboratory of Environmental Materials & Remediation Technologies, College of Chemistry and Environmental Engineering, Chongqing University of Arts and Sciences, Yongchuan 402160, China. catalystchen@126.com.
  • An Y; College of Pharmacy, Chongqing University of Arts and Sciences, Yongchuan 402160, China.
Org Biomol Chem ; 19(21): 4701-4705, 2021 06 02.
Article en En | MEDLINE | ID: mdl-33988213
ABSTRACT
A practical one-pot protocol has been developed to synthesize diarylacetylenes from arylaldehydes by treatment with 1-(arylmethyl)benzotriazoles and LiN(SiMe3)2. The reaction proceeded through imine formation, Mannich-type addition and double elimination to deliver products in up to 99% yields with broad substrate scope. In addition, gram-scale synthesis of 1-bromo-4-(phenylethynyl)benzene has been demonstrated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China