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Targeted pH switched europium complexes monitoring receptor internalisation in living cells.
Fradgley, Jack D; Starck, Matthieu; Laget, Michel; Bourrier, Emmanuel; Dupuis, Elodie; Lamarque, Laurent; Trinquet, Eric; Zwier, Jurriaan M; Parker, David.
Afiliación
  • Fradgley JD; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK. david.parker@dur.ac.uk.
  • Starck M; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK. david.parker@dur.ac.uk.
  • Laget M; Cisbio Bioassays, BP 84175, 30200 Codolet, France.
  • Bourrier E; Cisbio Bioassays, BP 84175, 30200 Codolet, France.
  • Dupuis E; Cisbio Bioassays, BP 84175, 30200 Codolet, France.
  • Lamarque L; Cisbio Bioassays, BP 84175, 30200 Codolet, France.
  • Trinquet E; Cisbio Bioassays, BP 84175, 30200 Codolet, France.
  • Zwier JM; Cisbio Bioassays, BP 84175, 30200 Codolet, France.
  • Parker D; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK. david.parker@dur.ac.uk.
Chem Commun (Camb) ; 57(47): 5814-5817, 2021 Jun 10.
Article en En | MEDLINE | ID: mdl-34002181
ABSTRACT
We report the design and evaluation of pH responsive luminescent europium(iii) probes that allow conjugation to targeting vectors to monitor receptor internalisation in cells. The approach adopted here can be used to tag proteins selectively and to monitor uptake into more acidic organelles, thereby enhancing the performance of time-resolved internalisation assays that require pH monitoring in real time.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancias Luminiscentes / Europio / Complejos de Coordinación / Receptor del Péptido 1 Similar al Glucagón Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancias Luminiscentes / Europio / Complejos de Coordinación / Receptor del Péptido 1 Similar al Glucagón Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido