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Plasma amyloid ß levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants.
Damotte, Vincent; van der Lee, Sven J; Chouraki, Vincent; Grenier-Boley, Benjamin; Simino, Jeannette; Adams, Hieab; Tosto, Giuseppe; White, Charles; Terzikhan, Natalie; Cruchaga, Carlos; Knol, Maria J; Li, Shuo; Schraen, Susanna; Grove, Megan L; Satizabal, Claudia; Amin, Najaf; Berr, Claudine; Younkin, Steven; Gottesman, Rebecca F; Buée, Luc; Beiser, Alexa; Knopman, David S; Uitterlinden, Andre; DeCarli, Charles; Bressler, Jan; DeStefano, Anita; Dartigues, Jean-François; Yang, Qiong; Boerwinkle, Eric; Tzourio, Christophe; Fornage, Myriam; Ikram, M Arfan; Amouyel, Philippe; de Jager, Phil; Reitz, Christiane; Mosley, Thomas H; Lambert, Jean-Charles; Seshadri, Sudha; van Duijn, Cornelia M.
Afiliación
  • Damotte V; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.
  • van der Lee SJ; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
  • Chouraki V; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Grenier-Boley B; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.
  • Simino J; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Adams H; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.
  • Tosto G; Gertrude C. Ford MIND Center, Department of Data Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • White C; Departments of Epidemiology, Neurology, and Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Terzikhan N; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.
  • Cruchaga C; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.
  • Knol MJ; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Li S; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
  • Schraen S; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Grove ML; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
  • Satizabal C; Department of Psychiatry, Washington University in St. Louis, Saint Louis, Missouri, USA.
  • Amin N; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Berr C; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
  • Younkin S; The Framingham Heart Study, Framingham, Massachusetts, USA.
  • Gottesman RF; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Buée L; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Beiser A; The Framingham Heart Study, Framingham, Massachusetts, USA.
  • Knopman DS; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Uitterlinden A; INSERM U1061, University of Montpellier, Montpellier, France.
  • DeCarli C; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
  • Bressler J; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.
  • DeStefano A; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Dartigues JF; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Yang Q; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.
  • Boerwinkle E; Institut National de la Santé et de la Recherche Medicale (INSERM, Université de Lille, Lille, France.
  • Tzourio C; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Fornage M; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
  • Ikram MA; The Framingham Heart Study, Framingham, Massachusetts, USA.
  • Amouyel P; Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • de Jager P; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Reitz C; Department of Neurology, University of California at Davis, Davis, California, USA.
  • Mosley TH; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
  • Lambert JC; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Seshadri S; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
  • van Duijn CM; The Framingham Heart Study, Framingham, Massachusetts, USA.
Alzheimers Dement ; 17(10): 1663-1674, 2021 10.
Article en En | MEDLINE | ID: mdl-34002480
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apolipoproteínas E / Ácido Aspártico Endopeptidasas / Precursor de Proteína beta-Amiloide / Secretasas de la Proteína Precursora del Amiloide / Presenilina-2 / Estudio de Asociación del Genoma Completo / Voluntarios Sanos / Amiloide Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Alzheimers Dement Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apolipoproteínas E / Ácido Aspártico Endopeptidasas / Precursor de Proteína beta-Amiloide / Secretasas de la Proteína Precursora del Amiloide / Presenilina-2 / Estudio de Asociación del Genoma Completo / Voluntarios Sanos / Amiloide Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Alzheimers Dement Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos