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Sarcopenia and serum biomarkers of oxidative stress after a 6-month physical activity intervention in women with metastatic breast cancer: results from the ABLE feasibility trial.
Delrieu, Lidia; Martin, Agnès; Touillaud, Marina; Pérol, Olivia; Morelle, Magali; Febvey-Combes, Olivia; Freyssenet, Damien; Friedenreich, Christine; Dufresne, Armelle; Bachelot, Thomas; Heudel, Pierre-Etienne; Trédan, Olivier; Crochet, Hugo; Bouhamama, Amine; Pilleul, Frank; Pialoux, Vincent; Fervers, Béatrice.
Afiliación
  • Delrieu L; Inter-University Laboratory of Human Movement Biology EA7424, University Claude Bernard Lyon 1, University of Lyon, 29 Boulevard du 11 Novembre 1918, 69622, Villeurbanne Cedex, France.
  • Martin A; Department of Prevention Cancer Environment, Léon Bérard Cancer Centre, Lyon, France.
  • Touillaud M; Inter-University Laboratory of Human Movement Biology EA7424, University of Lyon, University Jean Monnet Saint-Etienne, Saint-Etienne, France.
  • Pérol O; Department of Prevention Cancer Environment, Léon Bérard Cancer Centre, Lyon, France.
  • Morelle M; Inserm UA8, "Radiation: Defense, Health, Environment", Léon Bérard Cancer Center, Lyon, France.
  • Febvey-Combes O; Department of Prevention Cancer Environment, Léon Bérard Cancer Centre, Lyon, France.
  • Freyssenet D; Inserm UA8, "Radiation: Defense, Health, Environment", Léon Bérard Cancer Center, Lyon, France.
  • Friedenreich C; Inserm UA8, "Radiation: Defense, Health, Environment", Léon Bérard Cancer Center, Lyon, France.
  • Dufresne A; Department of Clinical Research and Innovation, Léon Bérard Cancer Centre, Lyon, France.
  • Bachelot T; Inter-University Laboratory of Human Movement Biology EA7424, University of Lyon, University Jean Monnet Saint-Etienne, Saint-Etienne, France.
  • Heudel PE; Department of Cancer Epidemiology and Prevention Research, CancerCare Alberta, Alberta Health Services, Calgary, AB, Canada.
  • Trédan O; Departments of Oncology and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Crochet H; Data Factory Team, Léon Bérard Cancer Centre, Lyon, France.
  • Bouhamama A; Data Factory Team, Léon Bérard Cancer Centre, Lyon, France.
  • Pilleul F; Data Factory Team, Léon Bérard Cancer Centre, Lyon, France.
  • Pialoux V; Data Factory Team, Léon Bérard Cancer Centre, Lyon, France.
  • Fervers B; Department of Medical Oncology, Léon Bérard Cancer Centre, Lyon, France.
Breast Cancer Res Treat ; 188(3): 601-613, 2021 Aug.
Article en En | MEDLINE | ID: mdl-34013451
ABSTRACT

PURPOSE:

Sarcopenia has been identified as an important prognostic factor for patients with cancer. This study aimed at exploring the potential associations between a 6-month physical activity intervention and muscle characteristics, sarcopenia, oxidative stress and toxicities in patients with metastatic breast cancer.

METHODS:

Women newly diagnosed with metastatic breast cancer (N = 49) participated in an unsupervised, personalized, 6-month physical activity intervention with activity tracker. Computerized tomography images at the third lumbar vertebra were analysed at baseline, three months and six months to assess sarcopenia (muscle mass index < 40 cm2/m2) and muscle quality (poor if muscle attenuation < 37.8 Hounsfield Units). Oxidative markers included plasma antioxidant enzymes (catalase, glutathione peroxidase and superoxide dismutase activities), prooxidant enzymes (NADPH oxidase and myeloperoxidase activities) and oxidative stress damage markers (advanced oxidation protein products, malondialdehyde (MDA) and DNA oxidation.

RESULTS:

At baseline 53% (mean age 55 years (SD 10.41)) were sarcopenic and 75% had poor muscle quality. Muscle cross sectional area, skeletal muscle radiodensity, lean body mass remained constant over the six months (p = 0.75, p = 0.07 and p = 0.75 respectively), but differed significantly between sarcopenic and non-sarcopenic patients at baseline and 6-months. Sarcopenic patients at baseline were more likely to have an increase of MDA (p = 0.02) at 6 months. Being sarcopenic during at least one moment during the 6-month study was associated with a higher risk of developing severe toxicities (grade > 2) (p = 0.02).

CONCLUSIONS:

This study suggests potential benefits of physical activity for maintenance of muscle mass. Sarcopenia can alter many parameters and disturb the pro and antioxidant balance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Sarcopenia Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Breast Cancer Res Treat Año: 2021 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Sarcopenia Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Breast Cancer Res Treat Año: 2021 Tipo del documento: Article País de afiliación: Francia