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Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase.
Zhu, Wei; Doubleday, Peter F; Butrin, Arseniy; Weerawarna, Pathum M; Melani, Rafael D; Catlin, Daniel S; Dwight, Timothy A; Liu, Dali; Kelleher, Neil L; Silverman, Richard B.
Afiliación
  • Zhu W; Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.
  • Doubleday PF; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.
  • Butrin A; Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
  • Weerawarna PM; Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.
  • Melani RD; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.
  • Catlin DS; Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
  • Dwight TA; Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.
  • Liu D; Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.
  • Kelleher NL; Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States.
  • Silverman RB; Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States.
J Am Chem Soc ; 143(21): 8193-8207, 2021 06 02.
Article en En | MEDLINE | ID: mdl-34014654
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ornitina-Oxo-Ácido Transaminasa / Inhibidores Enzimáticos Límite: Humans Idioma: En Revista: J Am Chem Soc Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ornitina-Oxo-Ácido Transaminasa / Inhibidores Enzimáticos Límite: Humans Idioma: En Revista: J Am Chem Soc Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos