Modulating Target Protein Biology Through the Re-mapping of Conformational Distributions Using Small Molecules.

Lawson, Alastair D G; MacCoss, Malcolm; Baeten, Dominique L; Macpherson, Alex; Shi, Jiye; Henry, Alistair J

Lawson, Alastair D G; MacCoss, Malcolm; Baeten, Dominique L; Macpherson, Alex; Shi, Jiye; Henry, Alistair J.

Afiliación

Lawson ADG; UCB Pharma, Slough, United Kingdom.
MacCoss M; Bohicket Consulting LLC, Seabrook Island, SC, United States.
Baeten DL; UCB Pharma, Slough, United Kingdom.
Macpherson A; UCB Pharma, Slough, United Kingdom.
Shi J; UCB Pharma, Slough, United Kingdom.
Henry AJ; UCB Pharma, Slough, United Kingdom.

Front Chem ; 9: 668186, 2021.

Article en En | MEDLINE | ID: mdl-34017820

Palabras clave

allosteric; conformational distributions; conformational sampling; conformer; drug discovery; molecular dynamics; protein-protein interactions; small molecule

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Chem Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Suiza

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