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Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions.
Dong, Xiao; Sun, Shixiang; Zhang, Lei; Kim, Seungsoo; Tu, Zhidong; Montagna, Cristina; Maslov, Alexander Y; Suh, Yousin; Wang, Tao; Campisi, Judith; Vijg, Jan.
Afiliación
  • Dong X; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Sun S; Institute on the Biology of Aging and Metabolism, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.
  • Zhang L; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Kim S; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Tu Z; Institute on the Biology of Aging and Metabolism, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.
  • Montagna C; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.
  • Maslov AY; Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine Mount Sinai, New York, NY, USA.
  • Suh Y; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Wang T; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Campisi J; Laboratory of Applied Genomic Technologies, Voronezh State University of Engineering Technology, Voronezh, Russia.
  • Vijg J; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.
Aging Cell ; 20(6): e13357, 2021 06.
Article en En | MEDLINE | ID: mdl-34018656
ABSTRACT
Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age-related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome-wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Expresión Génica / Telómero / Senescencia Celular Tipo de estudio: Etiology_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Aging Cell Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Expresión Génica / Telómero / Senescencia Celular Tipo de estudio: Etiology_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Aging Cell Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM