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Design and discovery of new antiproliferative 1,2,4-triazin-3(2H)-ones as tubulin polymerization inhibitors targeting colchicine binding site.
Eissa, Ibrahim H; Dahab, Mohammed A; Ibrahim, Mohamed K; Alsaif, Nawaf A; Alanazi, A Z; Eissa, Sally I; Mehany, Ahmed B M; Beauchemin, André M.
Afiliación
  • Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt. Electronic address: Ibrahimeissa@azhar.edu.eg.
  • Dahab MA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt; Centre for Catalysis Research and Innovation, Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ontario K1N6N5, Canada. Electronic address: mo
  • Ibrahim MK; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.
  • Alsaif NA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
  • Alanazi AZ; Department of pharmacology and toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
  • Eissa SI; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh, 13713, Saudi Arabia.
  • Mehany ABM; Department of Zoology, Faculty of Science (Boys), Al-Azhar University, Cairo, 11884, Egypt.
  • Beauchemin AM; Centre for Catalysis Research and Innovation, Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ontario K1N6N5, Canada.
Bioorg Chem ; 112: 104965, 2021 07.
Article en En | MEDLINE | ID: mdl-34020238
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triazinas / Tubulina (Proteína) / Diseño de Fármacos / Colchicina / Moduladores de Tubulina / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triazinas / Tubulina (Proteína) / Diseño de Fármacos / Colchicina / Moduladores de Tubulina / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos