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Dengue structural proteins as antiviral drug targets: Current status in the drug discovery & development.
S, Akshatha H; Pujar, Gurubasavaraj V; Sethu, Arun Kumar; Bhagyalalitha, Meduri; Singh, Manisha.
Afiliación
  • S AH; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Sri Shivarathreeshwara Nagara, Mysuru, 570015, India.
  • Pujar GV; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Sri Shivarathreeshwara Nagara, Mysuru, 570015, India. Electronic address: gvpujar@jssuni.edu.in.
  • Sethu AK; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Sri Shivarathreeshwara Nagara, Mysuru, 570015, India.
  • Bhagyalalitha M; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Sri Shivarathreeshwara Nagara, Mysuru, 570015, India.
  • Singh M; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Sri Shivarathreeshwara Nagara, Mysuru, 570015, India.
Eur J Med Chem ; 221: 113527, 2021 Oct 05.
Article en En | MEDLINE | ID: mdl-34020338
ABSTRACT
Dengue virus belongs to the class of RNA viruses and subclass of enveloped single-stranded positive-sense RNA virus. It causes dengue fever (DF), dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS), where DHF and DSS are life-threatening. Even though dengue is an age-old disease, it is still a mystery and continues to be a global threat. Numerous attempts have been carried out in the past few decades to eradicate the virus through vaccine and antiviral drugs, but still battle continues. In this review, the possible drug targets for discovery and development of potential antiviral drugs against structural proteins of dengue virus, the current development status of the antiviral drugs against dengue around the world, and challenges that need to be addressed to overcome the shortcomings in the process of drug discovery have been discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Proteínas Estructurales Virales / Dengue / Virus del Dengue / Desarrollo de Medicamentos Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Proteínas Estructurales Virales / Dengue / Virus del Dengue / Desarrollo de Medicamentos Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: India