Catalytic asymmetric preparation of pyrroloindolines: strategies and applications to total synthesis.
Chem Soc Rev
; 50(10): 5985-6012, 2021 May 21.
Article
en En
| MEDLINE
| ID: mdl-34027944
ABSTRACT
Pyrroloindolines are important and privileged polycyclic indoline motifs that are widely present in natural products and bio-significant molecules. From an organic chemistry perspective, their rigid tricyclic molecular architectures with a fully substituted carbon center at the C3a-position pose a great challenge to synthetic chemists. In a biological context, pyrroloindoline-containing alkaloids display a plethora of promising activities, making them significant in biological sciences and drug development. In the past few decades, pyrroloindoline and its analogues have emerged as appealing synthetic targets, attracting tremendous attention from the synthetic community. In this review, we summarize the state-of-the-art catalytic asymmetric synthesis of pyrroloindolines, as well as the related applications to the total synthesis of natural products.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirroles
/
Indoles
Idioma:
En
Revista:
Chem Soc Rev
Año:
2021
Tipo del documento:
Article
País de afiliación:
China