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Identification and validation of viral antigens sharing sequence and structural homology with tumor-associated antigens (TAAs).
Ragone, Concetta; Manolio, Carmen; Cavalluzzo, Beatrice; Mauriello, Angela; Tornesello, Maria Lina; Buonaguro, Franco M; Castiglione, Filippo; Vitagliano, Luigi; Iaccarino, Emanuela; Ruvo, Menotti; Tagliamonte, Maria; Buonaguro, Luigi.
Afiliación
  • Ragone C; Experimental Oncology - Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"- IRCCS, Naples, Italy.
  • Manolio C; Experimental Oncology - Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"- IRCCS, Naples, Italy.
  • Cavalluzzo B; Experimental Oncology - Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"- IRCCS, Naples, Italy.
  • Mauriello A; Experimental Oncology - Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"- IRCCS, Naples, Italy.
  • Tornesello ML; Esperimental Oncology - Molecular Biology and Viral Oncogenesis, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"- IRCCS, Naples, Italy.
  • Buonaguro FM; Esperimental Oncology - Molecular Biology and Viral Oncogenesis, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"- IRCCS, Naples, Italy.
  • Castiglione F; Institute for Applied Computing, CNR, Roma, Italy.
  • Vitagliano L; Institute for Biostructures and Bioimages, CNR, Roma, Italy.
  • Iaccarino E; Institute for Biostructures and Bioimages, CNR, Roma, Italy.
  • Ruvo M; Institute for Biostructures and Bioimages, CNR, Roma, Italy.
  • Tagliamonte M; Experimental Oncology - Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"- IRCCS, Naples, Italy l.buonaguro@istitutotumori.na.it m.tagliamonte@istitutotumori.na.it.
  • Buonaguro L; Experimental Oncology - Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"- IRCCS, Naples, Italy l.buonaguro@istitutotumori.na.it m.tagliamonte@istitutotumori.na.it.
J Immunother Cancer ; 9(5)2021 05.
Article en En | MEDLINE | ID: mdl-34049932
BACKGROUND: The host's immune system develops in equilibrium with both cellular self-antigens and non-self-antigens derived from microorganisms which enter the body during lifetime. In addition, during the years, a tumor may arise presenting to the immune system an additional pool of non-self-antigens, namely tumor antigens (tumor-associated antigens, TAAs; tumor-specific antigens, TSAs). METHODS: In the present study, we looked for homology between published TAAs and non-self-viral-derived epitopes. Bioinformatics analyses and ex vivo immunological validations have been performed. RESULTS: Surprisingly, several of such homologies have been found. Moreover, structural similarities between paired TAAs and viral peptides as well as comparable patterns of contact with HLA and T cell receptor (TCR) α and ß chains have been observed. Therefore, the two classes of non-self-antigens (viral antigens and tumor antigens) may converge, eliciting cross-reacting CD8+ T cell responses which possibly drive the fate of cancer development and progression. CONCLUSIONS: An established antiviral T cell memory may turn out to be an anticancer T cell memory, able to control the growth of a cancer developed during the lifetime if the expressed TAA is similar to the viral epitope. This may ultimately represent a relevant selective advantage for patients with cancer and may lead to a novel preventive anticancer vaccine strategy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células T de Memoria / Memoria Inmunológica / Epítopos / Antígenos de Neoplasias / Antígenos Virales Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Immunother Cancer Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células T de Memoria / Memoria Inmunológica / Epítopos / Antígenos de Neoplasias / Antígenos Virales Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Immunother Cancer Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido