Comparison of CD34<sup>+</sup> cells isolated from frozen cord blood and fresh adult peripheral blood of sickle cell disease patients in gene correction of the sickle mutation at late-stage erythroid differentiation.

Kumkhaek, Chutima; Uchida, Naoya; Tisdale, John F; Rodgers, Griffin P

Comparison of CD34⁺ cells isolated from frozen cord blood and fresh adult peripheral blood of sickle cell disease patients in gene correction of the sickle mutation at late-stage erythroid differentiation.

Kumkhaek, Chutima; Uchida, Naoya; Tisdale, John F; Rodgers, Griffin P.

Afiliación

Kumkhaek C; Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI)/National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), National Institutes of Health, Bethesda (NIH), Bethesda, MD, USA.
Uchida N; Cellular and Molecular Therapeutics Branch, National Heart, Lung, and Blood Institute (NHLBI)/National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), National Institutes of Health, Bethesda (NIH), Bethesda, MD, USA.
Tisdale JF; Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan.
Rodgers GP; Cellular and Molecular Therapeutics Branch, National Heart, Lung, and Blood Institute (NHLBI)/National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), National Institutes of Health, Bethesda (NIH), Bethesda, MD, USA.

Br J Haematol ; 194(5): e80-e84, 2021 09.

Article en En | MEDLINE | ID: mdl-34060073

Asunto(s)

Anemia de Células Falciformes/patología; Antígenos CD34/análisis; Células Eritroides/patología; Anemia de Células Falciformes/genética; Anemia de Células Falciformes/terapia; Antígenos CD34/genética; Conservación de la Sangre; Diferenciación Celular; Células Cultivadas; Células Eritroides/metabolismo; Sangre Fetal; Congelación; Edición Génica; Humanos; Mutación; Globinas beta/genética

Palabras clave

CD34+ cells; CRISPR/Cas9; cord blood; gene correction.; sickle mutation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígenos CD34 / Células Eritroides / Anemia de Células Falciformes Límite: Humans Idioma: En Revista: Br J Haematol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM

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