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Auricular reconstruction: where are we now? A critical literature review.
Humphries, Sarah; Joshi, Anil; Webb, William Richard; Kanegaonkar, Rahul.
Afiliación
  • Humphries S; Institute of Medical Sciences, Faculty of Medicine, Canterbury Christchurch University, Chatham Maritime, Kent, UK. sarahhumphries@doctors.org.uk.
  • Joshi A; Facial Plastics, University Hospital Lewisham, Lewisham, UK.
  • Webb WR; Institute of Medical Sciences, Faculty of Medicine, Canterbury Christchurch University, Chatham Maritime, Kent, UK.
  • Kanegaonkar R; Institute of Medical Sciences, Faculty of Medicine, Canterbury Christchurch University, Chatham Maritime, Kent, UK.
Eur Arch Otorhinolaryngol ; 279(2): 541-556, 2022 Feb.
Article en En | MEDLINE | ID: mdl-34076725
ABSTRACT

PURPOSE:

Deformities of the external ear can affect psychosocial well-being and hearing. Current gold-standard reconstructive treatment is autologous costal cartilage grafting despite the vast morbidity profile. Tissue engineering using stem cells and 3D printing can create patient-specific reconstructed auricles with superior cosmetic outcomes and reduced morbidity. This review critically analyses recent and breakthrough research in the field of regenerative medicine for the pinna, considering gaps in current literature and suggesting further steps to identify whether this could be the new gold-standard.

METHODS:

A literature review was conducted. PubMed (MEDLINE) and Cochrane databases were searched using key terms regenerative medicine, tissue engineering, 3D printing, biofabrication, auricular reconstruction, auricular cartilage, chondrocyte, outer ear and pinna. Studies in which tissue-engineered auricles were implanted into animal or human subjects were included. Exclusion criteria included articles not in English and not published within the last ten years. Titles, abstracts and full texts were screened. Reference searching was conducted and significant breakthrough studies included.

RESULTS:

8 studies, 6 animal and 2 human, were selected for inclusion. Strengths and weaknesses of each are discussed. Common limitations include a lack of human studies, small sample sizes and short follow-up times.

CONCLUSION:

Regenerative medicine holds significant potential to improve auricular reconstruction. To date there are no large multi-centred human studies in which tissue-engineered auricles have been implanted. However, recent human studies suggest promising results, raising the ever-growing possibility that tissue engineering is the future of auricular reconstruction. We aim to continue developing knowledge in this field.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Procedimientos de Cirugía Plástica / Pabellón Auricular Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Eur Arch Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Procedimientos de Cirugía Plástica / Pabellón Auricular Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Eur Arch Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido