Are Proinflammatory Cytokines Relevant for the Diagnosis of Prostate Cancer?
Anticancer Res
; 41(6): 3067-3073, 2021 Jun.
Article
en En
| MEDLINE
| ID: mdl-34083299
ABSTRACT
BACKGROUND/AIM:
Inflammation plays an important role in prostate cancer (PCa). We evaluated proinflammatory cytokines regarding differential diagnosis of PCa in men with PSA levels between 2-10 ng/ml. PATIENTS ANDMETHODS:
Serum samples of 79 men (PSA 2-10 ng/ml) were analyzed for 10 proinflammatory cytokines (IL-6, IL-8, TNF-α, IFN-γ, IL-10, IL-1ß, IL-2, IL-4, IL-12p70, IL-13) and results were evaluated regarding presence of PCa and disease severity.RESULTS:
Significant differences between PCa patients and controls were found for IL-6 (p=0.002), IL-8 (p=0.030), and TNF-α (p=0.009), although they were not predictors of PCa in a logistic regression analysis. In addition, IL-6 and TNF-α levels were significantly higher in patients with high-risk PCa (p<0.05). No significant differences were observed regarding the other cytokines.CONCLUSION:
In patients with PSA levels between 2-10 ng/ml, IL-6, IL-8, and TNF-α are associated with PCa, and IL-6 and TNF-α are associated with high-risk PCa.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
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Citocinas
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Mediadores de Inflamación
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Anticancer Res
Año:
2021
Tipo del documento:
Article