Influence of the diagnostic protocol and age on the prostate cancer incidence rate in Castilla y León according to the national registry 2010.
Actas Urol Esp (Engl Ed)
; 45(5): 383-390, 2021 Jun.
Article
en En, Es
| MEDLINE
| ID: mdl-34088438
ABSTRACT
OBJECTIVE:
Cross-sectional descriptive observational study of incidence and association, to determine whether the higher incidence of prostate cancer in Castilla y León (with respect to the national rate) could be due to modifiable factors. LOCATION University Hospital Río Hortega.PARTICIPANTS:
New prostate cancer diagnoses. MAIN MEASUREMENTS Incidence rate (IR). Age, family history, symptoms, comorbidity, rectal examination, ultrasound volume (cc), PSA (ng/mL), cylinders, volume cylinder ratio, Gleason, TNM and D'Amico groups.RESULTS:
Castilla y León showed the highest prostate cancer IR in Spain (141.1 per 100,000 inhabitants per year), with a peak of early incidence (65-74 years) and significant differences inâ¯<â¯64 and 65-74 years. Age at diagnosis was the lowest (Castilla y León, 66.9⯱7.1 vs. Spain, 69.1⯱â¯8.2 years; Pâ¯<â¯.001). No differences family history, symptoms, comorbidity and PSA. The number of cylinders was 10.7⯱â¯1.8. In multivariate analysis (AUCâ¯=â¯0.801; Pâ¯<â¯.001), they were more frequent in Castilla y León grade i rectal examination, non-palpable rectal examination, Gleasonâ¯<â¯6, stage T2c and the volume cylinder ratioâ¯<â¯6 (only inâ¯<â¯64 years OR 5.2; 95% CI 1.2-22-22.3; Pâ¯=â¯.027). In Spanish regions, volume cylinder ratio showed inverse correlation with IR inâ¯<â¯74 years, while age showed positive correlation in all age groups.CONCLUSIONS:
The higher prostate cancer IR in Castilla y León in 2010 was not associated to an older population. However, the biopsy technique influenced IR, as more cylinders were obtained in younger subjects, without conditioning overdiagnosis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
Tipo de estudio:
Diagnostic_studies
/
Guideline
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
/
Es
Revista:
Actas Urol Esp (Engl Ed)
Año:
2021
Tipo del documento:
Article