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Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity.
Hiltensperger, Michael; Beltrán, Eduardo; Kant, Ravi; Tyystjärvi, Sofia; Lepennetier, Gildas; Domínguez Moreno, Helena; Bauer, Isabel J; Grassmann, Simon; Jarosch, Sebastian; Schober, Kilian; Buchholz, Veit R; Kenet, Selin; Gasperi, Christiane; Öllinger, Rupert; Rad, Roland; Muschaweckh, Andreas; Sie, Christopher; Aly, Lilian; Knier, Benjamin; Garg, Garima; Afzali, Ali M; Gerdes, Lisa Ann; Kümpfel, Tania; Franzenburg, Sören; Kawakami, Naoto; Hemmer, Bernhard; Busch, Dirk H; Misgeld, Thomas; Dornmair, Klaus; Korn, Thomas.
Afiliación
  • Hiltensperger M; Institute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Beltrán E; Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
  • Kant R; Institute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Tyystjärvi S; Institute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Lepennetier G; Institute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Domínguez Moreno H; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Bauer IJ; Institute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Grassmann S; Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
  • Jarosch S; Institute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany.
  • Schober K; Institute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany.
  • Buchholz VR; Institute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany.
  • Kenet S; Institute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Munich, Germany.
  • Gasperi C; Institute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany.
  • Öllinger R; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Rad R; Institute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich, Munich, Germany.
  • Muschaweckh A; Institute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich, Munich, Germany.
  • Sie C; Institute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Aly L; Institute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Knier B; Institute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Garg G; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Afzali AM; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Gerdes LA; Institute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Kümpfel T; Institute for Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Franzenburg S; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Kawakami N; Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
  • Hemmer B; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Busch DH; Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
  • Misgeld T; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
  • Dornmair K; Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
  • Korn T; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Nat Immunol ; 22(7): 880-892, 2021 07.
Article en En | MEDLINE | ID: mdl-34099917
Asunto(s)
Autoinmunidad; Encéfalo/inmunología; Linaje de la Célula; Encefalomielitis Autoinmune Experimental/inmunología; Intestinos/inmunología; Piel/inmunología; Linfocitos T Colaboradores-Inductores/inmunología; Traslado Adoptivo; Animales; Autoinmunidad/efectos de los fármacos; Encéfalo/efectos de los fármacos; Encéfalo/metabolismo; Señalización del Calcio; Líquido Cefalorraquídeo/inmunología; Líquido Cefalorraquídeo/metabolismo; Encefalomielitis Autoinmune Experimental/tratamiento farmacológico; Encefalomielitis Autoinmune Experimental/genética; Encefalomielitis Autoinmune Experimental/metabolismo; Clorhidrato de Fingolimod/farmacología; Perfilación de la Expresión Génica; Genes Codificadores de los Receptores de Linfocitos T; Células HEK293; Humanos; Inmunosupresores/farmacología; Intestinos/efectos de los fármacos; Microscopía Intravital; Ratones Endogámicos C57BL; Ratones Noqueados; Microscopía Fluorescente; Esclerosis Múltiple Recurrente-Remitente/genética; Esclerosis Múltiple Recurrente-Remitente/inmunología; Esclerosis Múltiple Recurrente-Remitente/metabolismo; Fenotipo; Estudios Prospectivos; RNA-Seq; Receptores CXCR6/genética; Receptores CXCR6/metabolismo; Receptores Purinérgicos P2X7/genética; Receptores Purinérgicos P2X7/metabolismo; Análisis de la Célula Individual; Piel/efectos de los fármacos; Piel/metabolismo; Linfocitos T Colaboradores-Inductores/efectos de los fármacos; Linfocitos T Colaboradores-Inductores/metabolismo; Linfocitos T Colaboradores-Inductores/trasplante; Transcriptoma
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Encéfalo / Autoinmunidad / Linfocitos T Colaboradores-Inductores / Linaje de la Célula / Encefalomielitis Autoinmune Experimental / Intestinos Tipo de estudio: Observational_studies Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Encéfalo / Autoinmunidad / Linfocitos T Colaboradores-Inductores / Linaje de la Célula / Encefalomielitis Autoinmune Experimental / Intestinos Tipo de estudio: Observational_studies Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos