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Impact of dietary carbohydrate type and protein-carbohydrate interaction on metabolic health.
Wali, Jibran A; Milner, Annabelle J; Luk, Alison W S; Pulpitel, Tamara J; Dodgson, Tim; Facey, Harrison J W; Wahl, Devin; Kebede, Melkam A; Senior, Alistair M; Sullivan, Mitchell A; Brandon, Amanda E; Yau, Belinda; Lockwood, Glen P; Koay, Yen Chin; Ribeiro, Rosilene; Solon-Biet, Samantha M; Bell-Anderson, Kim S; O'Sullivan, John F; Macia, Laurence; Forbes, Josephine M; Cooney, Gregory J; Cogger, Victoria C; Holmes, Andrew; Raubenheimer, David; Le Couteur, David G; Simpson, Stephen J.
Afiliación
  • Wali JA; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia. jibran.wali@sydney.edu.au.
  • Milner AJ; Faculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia. jibran.wali@sydney.edu.au.
  • Luk AWS; The University of Sydney, ANZAC Research Institute, Sydney, New South Wales, Australia. jibran.wali@sydney.edu.au.
  • Pulpitel TJ; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Dodgson T; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Facey HJW; Faculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia.
  • Wahl D; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Kebede MA; Faculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia.
  • Senior AM; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Sullivan MA; Faculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia.
  • Brandon AE; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Yau B; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Lockwood GP; The University of Sydney, ANZAC Research Institute, Sydney, New South Wales, Australia.
  • Koay YC; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Ribeiro R; Faculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia.
  • Solon-Biet SM; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Bell-Anderson KS; Mater Research Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.
  • O'Sullivan JF; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Macia L; Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia.
  • Forbes JM; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Cooney GJ; Faculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia.
  • Cogger VC; The University of Sydney, ANZAC Research Institute, Sydney, New South Wales, Australia.
  • Holmes A; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Raubenheimer D; Heart Research Institute, The University of Sydney, Sydney, New South Wales, Australia.
  • Le Couteur DG; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Simpson SJ; Faculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia.
Nat Metab ; 3(6): 810-828, 2021 06.
Article en En | MEDLINE | ID: mdl-34099926
ABSTRACT
Reduced protein intake, through dilution with carbohydrate, extends lifespan and improves mid-life metabolic health in animal models. However, with transition to industrialised food systems, reduced dietary protein is associated with poor health outcomes in humans. Here we systematically interrogate the impact of carbohydrate quality in diets with varying carbohydrate and protein content. Studying 700 male mice on 33 isocaloric diets, we find that the type of carbohydrate and its digestibility profoundly shape the behavioural and physiological responses to protein dilution, modulate nutrient processing in the liver and alter the gut microbiota. Low (10%)-protein, high (70%)-carbohydrate diets promote the healthiest metabolic outcomes when carbohydrate comprises resistant starch (RS), yet the worst outcomes were with a 5050 mixture of monosaccharides fructose and glucose. Our findings could explain the disparity between healthy, high-carbohydrate diets and the obesogenic impact of protein dilution by glucose-fructose mixtures associated with highly processed diets.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbohidratos de la Dieta / Proteínas en la Dieta / Dieta / Metabolismo Energético / Homeostasis Tipo de estudio: Etiology_studies / Prognostic_studies Aspecto: Patient_preference Límite: Animals Idioma: En Revista: Nat Metab Año: 2021 Tipo del documento: Article País de afiliación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbohidratos de la Dieta / Proteínas en la Dieta / Dieta / Metabolismo Energético / Homeostasis Tipo de estudio: Etiology_studies / Prognostic_studies Aspecto: Patient_preference Límite: Animals Idioma: En Revista: Nat Metab Año: 2021 Tipo del documento: Article País de afiliación: Australia