Sex difference of mortality by age and body mass index in gastric cancer.
Dig Liver Dis
; 53(9): 1185-1191, 2021 Sep.
Article
en En
| MEDLINE
| ID: mdl-34112614
ABSTRACT
Mortality difference by age, sex, body mass index (BMI) in gastric cancer (GC) has been controversial. We evaluated sex-specific mortality by age and BMI. A total of 5961 patients diagnosed with GC from 2005 to 2013 in a single tertiary center were included and were followed until December 2017. The plot in goodness-of-fit-test by sex was crossed, so we performed sex-specific analysis. Overall mortality was lower in women than in men (adjusted hazard ratio [aHR], 0.72). Favor outcomes in women compared to men were observed among patients older than 60â¯yr (aHR, 0.64; 95% CI, 0.56-0.74), a BMI less than 25â¯kg/m2 (aHR, 0.69; 95% CI, 0.61-0.79), and stage I (aHR, 0.46; 95% CI, 0.38-0.56). In sex-specific analysis, mortality increased in age older than 60â¯yr in men, whereas it increased in both extreme ages (<40â¯yr and ≥ 70â¯yr) in women. Mortality by BMI was lowest at BMI of 25-29.9â¯kg/m2 and gradually increased according to decrease of BMI in men; aHR, 1.24 (23-24.9â¯kg/m2), 1.44 (18.5-22.9â¯kg/m2), and 2.54 (BMI<18.5â¯kg/m2). However, mortality decreased in patients with BMI ≥ 30â¯kg/m2 (aHR, 0.46) in women. The sex discrepancies in GC mortality by age and BMI suggest the need for sex-specific approaches to prognostic prediction.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
/
Índice de Masa Corporal
/
Factores Sexuales
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Dig Liver Dis
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Corea del Sur