Rigid and Compact Binuclear Bis-hydrated Gd-complexes as High Relaxivity MRI Agents.
Chemistry
; 27(46): 11811-11817, 2021 Aug 16.
Article
en En
| MEDLINE
| ID: mdl-34114699
ABSTRACT
The first binuclear Gd-complex of the 12-membered pyridine-based polyaminocarboxylate macrocyclic ligand PCTA was synthesized by C-C connection of the pyridine units through two different synthetic procedures. A dimeric AAZTA-ligand was also synthesized with the aim to compare the relaxometric results or the two ditopic Gd-complexes. Thus, the 1 H relaxometric study on [Gd2 PCTA2 (H2 O)4 ] and on [Gd2 AAZTA2 (H2 O)4 ]2- highlighted the remarkable rigidity and compactness of the two binuclear complexes, which results in molar relaxivities (per Gd), at 1.5â
T and 298â
K of ca. 12-12.6â
mM-1 s-1 with an increase of ca. 80 % at 1.5â
T and 298â
K (+70 % at 310â
K) with respect to the corresponding mononuclear complexes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos Organometálicos
/
Gadolinio
Idioma:
En
Revista:
Chemistry
Asunto de la revista:
QUIMICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Italia