Overexpression of dopamine receptor D2 promotes colorectal cancer progression by activating the ß-catenin/ZEB1 axis.
Cancer Sci
; 112(9): 3732-3743, 2021 Sep.
Article
en En
| MEDLINE
| ID: mdl-34118099
ABSTRACT
Colorectal cancer (CRC) is a recurring cancer that is often resistant to conventional therapies and therefore requires the development of molecular-based therapeutic approaches. Dopamine receptor D2 (DRD2) is associated with the growth of many types of tumors, but its oncogenic role in CRC is unclear. Here, we observed that elevated DRD2 expression was associated with a poor survival rate among patients with CRC. Depletion of DRD2 suppressed CRC cell growth and motility by downregulating ß-catenin/ZEB signaling in vitro and in vivo, whereas overexpression of DRD2 promoted CRC cell progression. Inhibition of DRD2 by the antagonist pimozide inhibited tumor growth and lymph node metastasis in vivo and enhanced the cytotoxic effects of conventional agents in vitro. Taken together, our findings indicate that targeting the DRD2/ß-catenin/ZEB1 signaling axis is a potentially promising therapeutic strategy for patients with CRC.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
/
Receptores de Dopamina D2
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Progresión de la Enfermedad
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Beta Catenina
/
Homeobox 1 de Unión a la E-Box con Dedos de Zinc
Tipo de estudio:
Prognostic_studies
Límite:
Aged
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Animals
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Cancer Sci
Año:
2021
Tipo del documento:
Article