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Lung Transplantation and the Era of the Sensitized Patient.
Young, Katherine A; Ali, Hakim A; Beermann, Kristi J; Reynolds, John M; Snyder, Laurie D.
Afiliación
  • Young KA; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC, United States.
  • Ali HA; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC, United States.
  • Beermann KJ; Department of Pharmacy, Duke University Hospital, Durham, NC, United States.
  • Reynolds JM; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC, United States.
  • Snyder LD; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC, United States.
Front Immunol ; 12: 689420, 2021.
Article en En | MEDLINE | ID: mdl-34122454
ABSTRACT
Long term outcomes in lung transplant are limited by the development of chronic lung allograft dysfunction (CLAD). Within the past several decades, antibody-mediated rejection (AMR) has been recognized as a risk factor for CLAD. The presence of HLA antibodies in lung transplant candidates, "sensitized patients" may predispose patients to AMR, CLAD, and higher mortality after transplant. This review will discuss issues surrounding the sensitized patient, including mechanisms of sensitization, implications within lung transplant, and management strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Pulmón / Tolerancia al Trasplante / Rechazo de Injerto / Histocompatibilidad / Antígenos HLA / Isoanticuerpos Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Pulmón / Tolerancia al Trasplante / Rechazo de Injerto / Histocompatibilidad / Antígenos HLA / Isoanticuerpos Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos