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Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1.
Marzook, Amaara; Chen, Shiqian; Pickford, Phil; Lucey, Maria; Wang, Yifan; Corrêa, Ivan R; Broichhagen, Johannes; Hodson, David J; Salem, Victoria; Rutter, Guy A; Tan, Tricia M; Bloom, Stephen R; Tomas, Alejandra; Jones, Ben.
Afiliación
  • Marzook A; Section of Endocrinology and Investigative Medicine, Imperial College London, London, United Kingdom.
  • Chen S; Section of Endocrinology and Investigative Medicine, Imperial College London, London, United Kingdom.
  • Pickford P; Section of Endocrinology and Investigative Medicine, Imperial College London, London, United Kingdom.
  • Lucey M; Section of Endocrinology and Investigative Medicine, Imperial College London, London, United Kingdom.
  • Wang Y; Section of Cell Biology and Functional Genomics, Imperial College London, London, United Kingdom.
  • Corrêa IR; New England Biolabs, Ipswich, MA, USA.
  • Broichhagen J; Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
  • Hodson DJ; Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, United Kingdom; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, United Kingdom; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and No
  • Salem V; Section of Endocrinology and Investigative Medicine, Imperial College London, London, United Kingdom; Department of Bioengineering, Imperial College London, London, United Kingdom.
  • Rutter GA; Section of Cell Biology and Functional Genomics, Imperial College London, London, United Kingdom; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
  • Tan TM; Section of Endocrinology and Investigative Medicine, Imperial College London, London, United Kingdom.
  • Bloom SR; Section of Endocrinology and Investigative Medicine, Imperial College London, London, United Kingdom.
  • Tomas A; Section of Cell Biology and Functional Genomics, Imperial College London, London, United Kingdom.
  • Jones B; Section of Endocrinology and Investigative Medicine, Imperial College London, London, United Kingdom.
Biochem Pharmacol ; 190: 114656, 2021 08.
Article en En | MEDLINE | ID: mdl-34129856
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Regulación de la Expresión Génica / Receptor del Péptido 1 Similar al Glucagón / Exenatida Límite: Animals / Humans / Male Idioma: En Revista: Biochem Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Regulación de la Expresión Génica / Receptor del Péptido 1 Similar al Glucagón / Exenatida Límite: Animals / Humans / Male Idioma: En Revista: Biochem Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido