Discovery and structure optimization of a novel corn herbicide, tolpyralate.
J Pestic Sci
; 46(2): 152-159, 2021 May 20.
Article
en En
| MEDLINE
| ID: mdl-34135677
Tolpyralate, a new selective postemergence herbicide developed for the weed control in corn, possesses a unique chemical structure with a 1-alkoxyethyl methyl carbonate group on the N-ethyl pyrazole moiety. This compound shows high herbicidal activity against many weed species, including glyphosate-resistant Amaranthus tuberculatus. Tolpyralate targets 4-hydroxyphenylpyruvate dioxygenase (4-HPPD), which is involved in the tyrosine degradation pathway. Inhibition of the enzyme destroys the chlorophyll, thereby killing the susceptible weeds. Details of tolpyralate discovery, structure optimization, and biological activities are described.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Pestic Sci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Japón