Graphical models for mean and covariance of multivariate longitudinal data.
Stat Med
; 40(23): 4977-4995, 2021 10 15.
Article
en En
| MEDLINE
| ID: mdl-34139788
ABSTRACT
Joint mean-covariance modeling of multivariate longitudinal data helps to understand the relative changes among multiple longitudinally measured and correlated outcomes. A key challenge in the analysis of multivariate longitudinal data is the complex covariance structure. This is due to the contemporaneous and cross-temporal associations between multiple longitudinal outcomes. Graphical and data-driven tools that can aid in visualizing the dependence patterns among multiple longitudinal outcomes are not readily available. In this work, we show the role of graphical techniques profile plots, and multivariate regressograms, in developing mean and covariance models for multivariate longitudinal data. We introduce an R package MLGM (Multivariate Longitudinal Graphical Models) to facilitate visualization and modeling mean and covariance patterns. Through two real studies, microarray data from the T-cell activation study and Mayo Clinic's primary biliary cirrhosis of the liver study, we show the key features of MLGM. We evaluate the finite sample performance of the proposed mean-covariance estimation approach through simulations.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estudios Longitudinales
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Stat Med
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos