Your browser doesn't support javascript.
loading
Cerebral Palsy in Very Preterm Infants: A Nine-Year Prospective Study in a French Population-Based Tertiary Center.
Chollat, Clément; Bertrand, Emmanuelle; Petit-Ledo, Alice; de Vansay, Caroline; Voisin, Caroline; Dabaj, Ivana; Gillibert, André; Marret, Stéphane.
Afiliación
  • Chollat C; INSERM U1245, Genetics and Pathophysiology of Neurodevelopmental Disorders Team, Institute of Research and Innovation in Biomedicine, Faculty of Medicine, Normandy University, Caen, France; Neonatal Intensive Care Unit, Port-Royal, Paris Center University Hospitals, APHP, Paris Descartes University,
  • Bertrand E; INSERM U1245, Genetics and Pathophysiology of Neurodevelopmental Disorders Team, Institute of Research and Innovation in Biomedicine, Faculty of Medicine, Normandy University, Caen, France; Department of Neonatal Pediatrics and Intensive Care-Neuropediatrics, CHU Rouen, Rouen, France.
  • Petit-Ledo A; Department of Neonatal Pediatrics and Intensive Care-Neuropediatrics, CHU Rouen, Rouen, France.
  • de Vansay C; Neonatal Intensive Care Unit, Le Havre Hospital, Le Havre, France.
  • Voisin C; Department of Neonatal Pediatrics and Intensive Care-Neuropediatrics, CHU Rouen, Rouen, France.
  • Dabaj I; INSERM U1245, Genetics and Pathophysiology of Neurodevelopmental Disorders Team, Institute of Research and Innovation in Biomedicine, Faculty of Medicine, Normandy University, Caen, France; Department of Neonatal Pediatrics and Intensive Care-Neuropediatrics, CHU Rouen, Rouen, France.
  • Gillibert A; Department of Biostatistics, CHU Rouen, Rouen, France.
  • Marret S; INSERM U1245, Genetics and Pathophysiology of Neurodevelopmental Disorders Team, Institute of Research and Innovation in Biomedicine, Faculty of Medicine, Normandy University, Caen, France; Department of Neonatal Pediatrics and Intensive Care-Neuropediatrics, CHU Rouen, Rouen, France. Electronic add
J Pediatr ; 237: 183-189.e6, 2021 Oct.
Article en En | MEDLINE | ID: mdl-34144033
ABSTRACT

OBJECTIVES:

To describe the prevalence of cerebral palsy (CP) at age 2 years in infants born before 33 weeks of gestation and to analyze the fetal neuroprotective effect of the antenatal administration of magnesium sulfate (MgSO4) treatment on CP. STUDY

DESIGN:

Preterm infants born before 33 weeks of gestation and discharged from the Rouen University Hospital's Neonatal Intensive Care Unit between 2007 and 2015 were included. At age 2 years, pediatricians of the perinatal network of Eure and Seine-Maritime counties administered standardized questionnaires analyzing motor, cognitive, and behavioral items, derived from the Denver and Amiel-Tison scales. A routine protocol based on MgSO4 infusion was introduced in 2010. The primary outcome measure was the occurrence of CP according to the Surveillance of Cerebral Palsy in Europe network definition.

RESULTS:

A total of 1759 very preterm infants were included, among whom 138 (7.8%) died and 148 (9.1%) were lost to follow-up. Assuming that those lost to follow-up had no CP, at 2 years, 55 of 1621 infants (3.4%; 95% CI, 2.6%-4.4%) had CP. After statistical adjustment for birth term and antenatal corticosteroid use, a significant decrease in CP was observed after implementation of a protocol of MgSO4 administration in mothers before imminent preterm birth at <33 weeks of gestation (aOR, 0.53; 95% CI, 0.29-0.98; P = .04).

CONCLUSIONS:

The prevalence of CP at 2 years after very preterm birth was low. The implementation of a neuroprotective protocol with MgSO4 was associated with reduced CP occurrence; however, several relevant limitations must be considered for interpretation.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atención Prenatal / Tocolíticos / Parálisis Cerebral / Nacimiento Prematuro / Sulfato de Magnesio Tipo de estudio: Guideline / Observational_studies / Risk_factors_studies Límite: Child, preschool / Female / Humans / Male / Pregnancy País/Región como asunto: Europa Idioma: En Revista: J Pediatr Año: 2021 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atención Prenatal / Tocolíticos / Parálisis Cerebral / Nacimiento Prematuro / Sulfato de Magnesio Tipo de estudio: Guideline / Observational_studies / Risk_factors_studies Límite: Child, preschool / Female / Humans / Male / Pregnancy País/Región como asunto: Europa Idioma: En Revista: J Pediatr Año: 2021 Tipo del documento: Article