Longitudinal changes in physical and mental health of older adults with chronic hepatitis B infection: Trajectories and predictors.
Prev Med Rep
; 23: 101432, 2021 Sep.
Article
en En
| MEDLINE
| ID: mdl-34150482
ABSTRACT
Despite the increasing health burden of chronic hepatitis B (CHB) in aging populations, little is known about the course of health-related quality of life (HRQoL) changes. We aimed to assess individual-level longitudinal HRQoL changes in elderly patients with CHB and to examine their correlates. A prospective 5.1 years-cohort study was conducted in community-dwelling adults aged 55 years with hepatitis B surface antigen-positive. Participants underwent serial measurement of HRQoL using the short-form (12) health survey version 2. Of 503 participants, 82.7% remained in good physical health throughout the study period, whereas 9.1% had declining physical health and 8.2% were in poor physical health. We likewise identified three trajectories of mental health changes ("good mental health" [86.9%], "declining mental health" [6.8%], and "poor mental health" [6.4%]). Three baseline characteristics were independently associated with a lower likelihood of remaining physically or mentally healthy sarcopenic obesity (odds ratio [OR] with 95% confidence interval [95% CI] of 7.5 [2.8-20.5] for poor physical health, 3.1 [1.1-8.4] for declining physical health, 4.3 [1.4-13.0] for poor mental health), a higher number of metabolic abnormalities (OR [95% CI] of 3.6 [1.6-8.0] for poor physical health) and depressed mood (OR [95% CI] of 21.7 [5.8-81.0] for poor physical health, 5.3 [1.4-19.9] for declining physical health, 83.1 [19.7-350.2] for poor mental health, 13.6 [2.9-64.8] for declining mental health). In conclusion, in a cohort of elderly patients with CHB, we demonstrated the heterogeneity and nonlinearity of HRQoL changes and their associations with variations in specific extrahepatic organs/systems.
95% CI, 95% confidence interval; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Aging; BIC, Bayesian information criterion; BMI, body mass index; BP, blood pressure; CES-D, Center for Epidemiological Studies Depression; CHB, chronic hepatitis B; CV, coefficient of variation; FIB-4, Fibrosis-4 Index for Liver Fibrosis; Geriatric assessment; Group-based trajectory modeling; HALST, Healthy Aging Longitudinal Study in Taiwan; HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; HOMA-IR, Homeostasis Model Assessment of Insulin Resistance; HRQoL, health-related quality of life; Health-related quality of life; Healthy Aging Longitudinal Study in Taiwan (HALST); MCS, Mental Component Summary; MMSE, Mini-Mental State Examination; OR, odds ratio; PCS, Physical Component Summary; SF-12v2, the Short Form (12) Health Survey version 2; hsCRP, high-sensitivity C-reactive protein
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspecto:
Patient_preference
Idioma:
En
Revista:
Prev Med Rep
Año:
2021
Tipo del documento:
Article
País de afiliación:
Taiwán