Genotype-specific reduction in methyl nitrosourea (MNU) induced sister chromatid exchanges (SCE) in vivo during aging.
Experientia
; 44(9): 782-5, 1988 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-3416998
ABSTRACT
We studied mice from five strains (BALB/c, C3H/HeSnJ, C57BL/6J, Csb and 129/ReJ) at two ages (young, 10 +/- 1 weeks; and old, 67 +/- 3 weeks) for the induction of sister chromatid exchanges (SCEs) in vivo by methyl nitrosourea (MNU). The SCE frequency is genotype-specific. The F1 phenotype resembles the 'low' responding parent. SCE induction is significantly lower in the older animals of each strain than their younger counterparts, and the reduction of SCE/cell with old age is strain-specific. A general explanation for these results must include strain differences in relative mutagenic sensitivity, genotype-specific pattern of reduction in DNA repair and other such factors affecting SCE formation, with old age.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Intercambio de Cromátides Hermanas
/
Envejecimiento
/
Metilnitrosourea
/
Ratones Endogámicos
Límite:
Animals
Idioma:
En
Revista:
Experientia
Año:
1988
Tipo del documento:
Article
País de afiliación:
Canadá