Microparticles from human the lower airway show inhibitory activity against respiratory syncytial virus.
Arch Virol
; 166(9): 2579-2584, 2021 Sep.
Article
en En
| MEDLINE
| ID: mdl-34170427
ABSTRACT
Airway microparticles (MPs) have been shown previously to inhibit influenza virus by trapping virions on their surface through their surface viral receptor. It was hypothesized that airway MPs may carry most of the epithelial cell surface molecules, including receptors for respiratory viruses, and may be able to inhibit various respiratory viruses. We show here that MPs from human bronchoalveolar lavage (BAL) can inhibit respiratory syncytial virus (RSV). Those MPs stained positive for the RSV receptor, CX3CR1. Furthermore, incubating the MPs with a monoclonal antibody against CX3CR1 reduced the anti-RSV activity. These data indicate that MPs can contribute to respiratory innate antiviral defense.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Sistema Respiratorio
/
Virus Sincitial Respiratorio Humano
/
Infecciones por Virus Sincitial Respiratorio
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Arch Virol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Tailandia