Blood eosinophil counts in the general population and airways disease: a comprehensive review and meta-analysis.
Eur Respir J
; 59(1)2022 01.
Article
en En
| MEDLINE
| ID: mdl-34172466
ABSTRACT
BACKGROUND:
The clinical context for using blood eosinophil (EOS) counts as treatment-response biomarkers in asthma and COPD requires better understanding of EOS distributions and ranges. We describe EOS distributions and ranges published in asthma, COPD, control (non-asthma/COPD) and general populations.METHODS:
We conducted a comprehensive literature review and meta-analysis of observational studies (January 2008 to November 2018) that included EOS counts in asthma, severe asthma, COPD, control and general populations. Excluded studies had total sample sizes <200, EOS as inclusion criterion, hospitalised population only and exclusively paediatric participants.RESULTS:
Overall, 91 eligible studies were identified, most had total-population-level data available asthma (39 studies), severe asthma (12 studies), COPD (23 studies), control (seven studies) and general populations (14 studies); some articles reported data for multiple populations. Reported EOS distributions were right-skewed (seven studies). Reported median EOS counts ranged from 157-280â cells·µL-1 (asthma, 22 studies); 200-400â cells·µL-1 (severe asthma, eight studies); 150-183â cells·µL-1 (COPD, six studies); and 100-160â cells·µL-1 (controls, three studies); and 100-200â cells·µL-1 (general populations, six studies). The meta-analysis showed that observed variability was mostly between studies rather than within studies. Factors reportedly associated with higher blood EOS counts included current smoking, positive skin-prick test, elevated total IgE, comorbid allergic rhinitis, age ≤18â years, male sex, spirometric asthma/COPD diagnosis, metabolic syndrome and adiposity.CONCLUSION:
EOS distribution and range varied by study population, and were affected by clinical factors including age, smoking history and comorbidities, which, regardless of severity, should be considered during treatment decision-making.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos Respiratorios
/
Asma
/
Enfermedad Pulmonar Obstructiva Crónica
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Systematic_reviews
Límite:
Adolescent
/
Child
/
Humans
/
Male
Idioma:
En
Revista:
Eur Respir J
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido