Reappraising the role of the vagus nerve in GLP-1-mediated regulation of eating.
Br J Pharmacol
; 179(4): 584-599, 2022 02.
Article
en En
| MEDLINE
| ID: mdl-34185884
ABSTRACT
Here, we provide a focused review of the evidence for the roles of the vagus nerve in mediating the regulatory effects of peripherally and centrally produced GLP-1 on eating behaviour and energy balance. We particularly focus on recent studies which have used selective genetic, viral, and transcriptomic approaches to provide important insights into the anatomical and functional organisation of GLP-1-mediated gut-brain signalling pathways. A number of these studies have challenged canonical ideas of how GLP-1 acts in the periphery and the brain to regulate eating behaviour, with important implications for the development of pharmacological treatments for obesity. LINKED ARTICLES This article is part of a themed issue on GLP1 receptor ligands (BJP 75th Anniversary). To view the other articles in this section visit http//onlinelibrary.wiley.com/doi/10.1111/bph.v179.4/issuetoc.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptido 1 Similar al Glucagón
/
Receptor del Péptido 1 Similar al Glucagón
Límite:
Humans
Idioma:
En
Revista:
Br J Pharmacol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido