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Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease.
Siddiqi, Shan H; Schaper, Frederic L W V J; Horn, Andreas; Hsu, Joey; Padmanabhan, Jaya L; Brodtmann, Amy; Cash, Robin F H; Corbetta, Maurizio; Choi, Ki Sueng; Dougherty, Darin D; Egorova, Natalia; Fitzgerald, Paul B; George, Mark S; Gozzi, Sophia A; Irmen, Frederike; Kuhn, Andrea A; Johnson, Kevin A; Naidech, Andrew M; Pascual-Leone, Alvaro; Phan, Thanh G; Rouhl, Rob P W; Taylor, Stephan F; Voss, Joel L; Zalesky, Andrew; Grafman, Jordan H; Mayberg, Helen S; Fox, Michael D.
Afiliación
  • Siddiqi SH; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA. shsiddiqi@bwh.harvard.edu.
  • Schaper FLWVJ; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. shsiddiqi@bwh.harvard.edu.
  • Horn A; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA.
  • Hsu J; Department of Neurology, Harvard Medical School, Boston, MA, USA.
  • Padmanabhan JL; Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.
  • Brodtmann A; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA.
  • Cash RFH; Department of Neurology, Harvard Medical School, Boston, MA, USA.
  • Corbetta M; Movement Disorders and Neuromodulation Unit, Department for Neurology, Charité University Medicine Berlin, Berlin, Germany.
  • Choi KS; University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Dougherty DD; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA.
  • Egorova N; Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Victoria, Australia.
  • Fitzgerald PB; Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Victoria, Australia.
  • George MS; Department of Biomedical Engineering, The University of Melbourne, Melbourne, Victoria, Australia.
  • Gozzi SA; Department of Neuroscience, Padova Neuroscience Center (PNC), Venetian Institute of Molecular Medicine (VIMM), University of Padova, Padova, Italy.
  • Irmen F; Departments of Neurology, Radiology, Bioengineering, and Neuroscience, Washington University, St. Louis, MO, USA.
  • Kuhn AA; Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Johnson KA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
  • Naidech AM; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
  • Pascual-Leone A; Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia.
  • Phan TG; The Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia.
  • Rouhl RPW; Epworth Centre for Innovation in Mental Health, Epworth Healthcare and Monash University Department of Psychiatry, Camberwell, Victoria, Australia.
  • Taylor SF; Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina, Charleston, SC, USA.
  • Voss JL; Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
  • Zalesky A; Department of Neurology, Monash Health and Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.
  • Grafman JH; Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
  • Mayberg HS; Movement Disorders and Neuromodulation Unit, Department for Neurology, Charité University Medicine Berlin, Berlin, Germany.
  • Fox MD; School of Medicine, Florida State University, Tallahassee, FL, USA.
Nat Hum Behav ; 5(12): 1707-1716, 2021 12.
Article en En | MEDLINE | ID: mdl-34239076
Damage to specific brain circuits can cause specific neuropsychiatric symptoms. Therapeutic stimulation to these same circuits may modulate these symptoms. To determine whether these circuits converge, we studied depression severity after brain lesions (n = 461, five datasets), transcranial magnetic stimulation (n = 151, four datasets) and deep brain stimulation (n = 101, five datasets). Lesions and stimulation sites most associated with depression severity were connected to a similar brain circuit across all 14 datasets (P < 0.001). Circuits derived from lesions, deep brain stimulation and transcranial magnetic stimulation were similar (P < 0.0005), as were circuits derived from patients with major depression versus other diagnoses (P < 0.001). Connectivity to this circuit predicted out-of-sample antidepressant efficacy of transcranial magnetic stimulation and deep brain stimulation sites (P < 0.0001). In an independent analysis, 29 lesions and 95 stimulation sites converged on a distinct circuit for motor symptoms of Parkinson's disease (P < 0.05). We conclude that lesions, transcranial magnetic stimulation and DBS converge on common brain circuitry that may represent improved neurostimulation targets for depression and other disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Estimulación Encefálica Profunda / Trastornos Mentales Tipo de estudio: Diagnostic_studies Límite: Female / Humans / Male Idioma: En Revista: Nat Hum Behav Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Estimulación Encefálica Profunda / Trastornos Mentales Tipo de estudio: Diagnostic_studies Límite: Female / Humans / Male Idioma: En Revista: Nat Hum Behav Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido