Direct visualization and profiling of protein misfolding and aggregation in live cells.
Curr Opin Chem Biol
; 64: 116-123, 2021 10.
Article
en En
| MEDLINE
| ID: mdl-34246835
Over the past few years, research tools have been developed to monitor the multistep protein aggregation process in live cells, a process that has been associated with a growing number of human diseases. Herein, we describe recent advances in methods that can either survey the distribution of aggregation at the level of the cellular proteome using mass spectroscopy or discern the multistep aggregation process of specific proteins of interest via fluorescence signals. Future development and application of such technologies are expected to provide insights on mechanisms, diagnosis, and treatment of diseases rooted in protein aggregation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pliegue de Proteína
/
Agregado de Proteínas
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Chem Biol
Asunto de la revista:
BIOQUIMICA
Año:
2021
Tipo del documento:
Article
Pais de publicación:
Reino Unido