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New oligomeric neolignans from the leaves of Magnolia officinalis var. biloba.
Vu, Van-Tuan; Xu, Xiao-Juan; Chen, Kang; Nguyen, Manh-Tuyen; Nguyen, Bich-Ngoc; Pham, Giang-Nam; Kong, Ling-Yi; Luo, Jian-Guang.
Afiliación
  • Vu VT; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Xu XJ; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Chen K; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Nguyen MT; Department of Traditional Medicine, Hanoi University of Pharmacy, Hanoi, Vietnam.
  • Nguyen BN; Department of Traditional Medicine, Hanoi University of Pharmacy, Hanoi, Vietnam.
  • Pham GN; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
  • Kong LY; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpu_lykong@126.com.
  • Luo JG; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: luojg@cpu.edu.cn.
Chin J Nat Med ; 19(7): 491-499, 2021 Jul.
Article en En | MEDLINE | ID: mdl-34247772
ABSTRACT
Six new oligomeric neolignans including two trimeric neolignans (1 and 2) and four dimeric neolignans (3-6) were isolated from the leaves of Magnolia officinalis var. biloba. Their structures were determined based on HR-ESIMS and NMR data, as well as electronic circular dichroism (ECD) calculations. Compound 1 is formed from two obovatol moieties directly linked to an aromatic ring of the remaining obovatol moiety, which is an unprecedented type of linkage between monomers. All isolates were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 1 and 3 showed significantly inhibitory activities with IC50 values of 6.04 and 3.26 µmol·L-1, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lignanos / Magnolia Límite: Animals Idioma: En Revista: Chin J Nat Med Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: CHINA / CN / REPUBLIC OF CHINA
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lignanos / Magnolia Límite: Animals Idioma: En Revista: Chin J Nat Med Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: CHINA / CN / REPUBLIC OF CHINA