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Palladium-Catalyzed Cascade Difluoroalkylation and Phosphinoylation of 2-Vinyloxy Arylalkynes: Selective Synthesis of Difluoroalkyl-Containing Tetrasubstituted Alkenylphosphine Oxides.
Zhang, Pengbo; Yu, Guo; Zhao, Ning; Zhang, Shanshan; Zhang, Minghui; Wang, Longyu; Li, Zhaoting; Ying, Jianxi; Gao, Xia.
Afiliación
  • Zhang P; School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
  • Yu G; School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
  • Zhao N; Henan Institute of Technology, Xinxiang, Henan 453003, PR China.
  • Zhang S; School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
  • Zhang M; School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
  • Wang L; School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
  • Li Z; School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
  • Ying J; Institute of Drug Discovery Technology, Ningbo University, No.818 Fenghua Road, Ningbo, Zhejiang 315211, China.
  • Gao X; School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
J Org Chem ; 86(15): 10105-10117, 2021 08 06.
Article en En | MEDLINE | ID: mdl-34259510
ABSTRACT
A Pd-catalyzed difluoroalkylation/cyclization/phosphinoylation of 2-vinyloxy arylalkynes with ethyl difluoroiodoacetate and diarylphosphine oxides has been successfully developed. This reaction allows the formation of Csp3-CF2, Csp3-Csp2, and Csp2-P(O) bonds in one step, providing a straightforward route to difluoroalkyl-containing tetrasubstituted alkenylphosphine oxides with complete stereoselectivities under mild conditions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxidos / Paladio Idioma: En Revista: J Org Chem Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxidos / Paladio Idioma: En Revista: J Org Chem Año: 2021 Tipo del documento: Article País de afiliación: China