Metallaphotoredox-Catalyzed C-S Cross-Coupling between Heteroaryl Bromides and α-Thioacetic Acids to Access Biaryl Thioethers.

Metallaphotoredox-catalyzed C-S cross-coupling between heteroaryl bromides and α-thioacetic acids to form biaryl thioethers is described herein. This transformation allows for cross-coupling between building blocks containing reactive functional groups, nitrogen heterocycles, and pharmaceutically relevant scaffolds. Mechanistic experiments indicate a unique means by which this C-S cross-coupling occurs.