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Neurovascular protection of salvianolic acid B and ginsenoside Rg1 combination against acute ischemic stroke in rats.
Fu, Yao; Xing, Rongrong; Wang, Linlin; Yang, Li; Jiang, Baohong.
Afiliación
  • Fu Y; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian.
  • Xing R; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Wang L; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Yang L; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Jiang B; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian.
Neuroreport ; 32(13): 1140-1146, 2021 09 08.
Article en En | MEDLINE | ID: mdl-34284451
ABSTRACT
Ischemic stroke continues to be a major global health problem associated with considerable mortality and morbidity. Thus, it is still targeted by researchers for developing new strategies or drugs to alleviate the lesion of stroke. In the present study, both the permanent occlusion of the middle cerebral artery (MCAO) model and the restoration of cerebral blood flow after middle cerebral artery occlusion (CI/R) model were set up for evaluating the efficiency of salvianolic acid B and ginsenoside Rg1 combination (SalB-Rg1). SalB-Rg1 decreased infarct area through 3,5-triphenyltetrazolium chloride stain and improved neurological behavior through Longa Score or Left-Biased Swings on both MCAO rats and CI/R rats. Neural protection of SalB-Rg1 against ischemia or ischemic reperfusion injury was evidenced by the inhibition of nucleus pyknosis, liquefaction necrosis through H&E stain and Nissl stain. Furthermore, protection of SalB-Rg1 on blood-brain barrier (BBB) was more significant on CI/R rats, accompanying with the downregulation of matrix metalloproteinase-2 and matrix metalloproteinase-9, and recovery of zonula occludens-1 expression. These results provide compelling evidence that SalB-Rg1 holds the potential to be developed as an optimal therapeutic strategy to alleviate the injury of ischemia or ischemic reperfusion.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Fármacos Neuroprotectores / Ginsenósidos / Alquenos / Polifenoles / Accidente Cerebrovascular Isquémico Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neuroreport Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Fármacos Neuroprotectores / Ginsenósidos / Alquenos / Polifenoles / Accidente Cerebrovascular Isquémico Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neuroreport Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article