A placental specific miRNA miR-517a-3p exerts anti-human cytomegalovirus activity.
Placenta
; 112: 62-65, 2021 09 01.
Article
en En
| MEDLINE
| ID: mdl-34298423
ABSTRACT
Human cytomegalovirus congenital infection is the leading non-genetic cause of fetal malformation in developed countries. There are currently no safe antivirals for use during pregnancy. Placental trophoblast cells specifically secrete exosomes containing miRNA from the chromosome 19 miRNA cluster (C19MC) which confer viral resistance to recipient cells. We show the highly expressed C19MC miRNA miR-517a-3p inhibits HCMV replication and viral protein expression in both fibroblast and trophoblast cell cultures (71.6% and 50.4% inhibition of HCMV DNA at 7 days post infection respectively; p < 0.05). This naturally occurring molecule has potential for opening-up antiviral therapeutic strategies for pregnancy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
/
Citomegalovirus
/
MicroARNs
Límite:
Female
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Humans
/
Pregnancy
Idioma:
En
Revista:
Placenta
Año:
2021
Tipo del documento:
Article
País de afiliación:
Australia