Adenosine-to-inosine Alu RNA editing controls the stability of the pro-inflammatory long noncoding RNA NEAT1 in atherosclerotic cardiovascular disease.

Vlachogiannis, Nikolaos I; Sachse, Marco; Georgiopoulos, Georgios; Zormpas, Eleftherios; Bampatsias, Dimitrios; Delialis, Dimitrios; Bonini, Francesca; Galyfos, George; Sigala, Fragiska; Stamatelopoulos, Kimon; Gatsiou, Aikaterini; Stellos, Konstantinos

Adenosine-to-inosine Alu RNA editing controls the stability of the pro-inflammatory long noncoding RNA NEAT1 in atherosclerotic cardiovascular disease.

Vlachogiannis, Nikolaos I; Sachse, Marco; Georgiopoulos, Georgios; Zormpas, Eleftherios; Bampatsias, Dimitrios; Delialis, Dimitrios; Bonini, Francesca; Galyfos, George; Sigala, Fragiska; Stamatelopoulos, Kimon; Gatsiou, Aikaterini; Stellos, Konstantinos.

Afiliación

Vlachogiannis NI; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK; Department of Cardiology, Freeman Hospital, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Sachse M; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK; Vascular Inflammation and RNA Metabolism Laboratory, Institute for Vascular Signalling, JW Goethe University Frankfurt, Frankfurt am Main, Germany.
Georgiopoulos G; Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Zormpas E; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.
Bampatsias D; Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Delialis D; Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Bonini F; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK; Vascular Inflammation and RNA Metabolism Laboratory, Institute for Vascular Signalling, JW Goethe University Frankfurt, Frankfurt am Main, Germany.
Galyfos G; First Propaedeutic Department of Surgery, National and Kapodistrian University of Athens, Hippocration Hospital, Athens, Greece.
Sigala F; First Propaedeutic Department of Surgery, National and Kapodistrian University of Athens, Hippocration Hospital, Athens, Greece.
Stamatelopoulos K; Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Gatsiou A; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK. Electronic address: aikaterini.gatsiou@ncl.ac.uk.
Stellos K; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK; Department of Cardiology, Freeman Hospital, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Vascular Inflammation and RNA Metabolism Laboratory,

J Mol Cell Cardiol ; 160: 111-120, 2021 11.

Article en En | MEDLINE | ID: mdl-34302813

Asunto(s)

Adenosina/metabolismo; Elementos Alu/genética; Aterosclerosis/sangre; Enfermedad de la Arteria Coronaria/sangre; Inosina/metabolismo; Placa Aterosclerótica/sangre; Edición de ARN/genética; Estabilidad del ARN/genética; ARN Largo no Codificante/metabolismo; Transducción de Señal/genética; Adenosina Desaminasa/genética; Adenosina Desaminasa/metabolismo; Adulto; Anciano; Anciano de 80 o más Años; Aterosclerosis/genética; Sitios de Unión; Células Cultivadas; Estudios de Cohortes; Enfermedad de la Arteria Coronaria/genética; Femenino; Silenciador del Gen; Ribonucleoproteína Nuclear Heterogénea D0/genética; Ribonucleoproteína Nuclear Heterogénea D0/metabolismo; Células Endoteliales de la Vena Umbilical Humana; Humanos; Leucocitos Mononucleares/metabolismo; Masculino; Persona de Mediana Edad; Placa Aterosclerótica/genética; ARN Largo no Codificante/genética; Proteínas de Unión al ARN/genética; Proteínas de Unión al ARN/metabolismo; Transfección

Palabras clave

A-to-I RNA editing; ADAR1; AUF1; Alu; Atherosclerosis; NEAT1; RNA stability; lncRNA

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Transducción de Señal / Adenosina / Edición de ARN / Elementos Alu / Estabilidad del ARN / Aterosclerosis / Placa Aterosclerótica / ARN Largo no Codificante / Inosina Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Mol Cell Cardiol Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google