Changes and significance of serum FGF21 in children with primary nephrotic syndrome and chronic renal failure.

ABSTRACT

OBJECTIVE: The aim of the study was to investigate the changes and significance of serum fibroblast growth factor 21 (FGF21) in children with primary nephrotic syndrome (PNS) and chronic renal failure. METHODS: Pediatric patients with active PNS and normal renal function (the nephrotic syndrome group), pediatric patients with chronic renal failure (the renal failure group), and children who had healthy physical examinations (the control group) were included. The serum levels of FGF21, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) were measured by enzyme-linked immunosorbent assay (ELISA), and the serum albumin and 24 h urine protein were measured in the PNS group. RESULTS: Compared with the normal control group, the level of serum FGF21 in the PNS group and the renal failure group increased significantly (P < 0.05). The TC, TG, HDL-C, and LDL-C levels increased significantly in the PNS group (P < 0.05). The levels of TG and HDL-C increased significantly in the renal failure group (P < 0.05). The levels of TC, HDL-C, and LDL-C in the renal failure group were lower than those in the PNS group (P < 0.05). There was no significant difference in TG level between the two groups (P > 0.05). CONCLUSION: The level of serum FGF21 may be correlated with the occurrence and development of nephrosis in children. The higher the level of serum FGF21, the more serious the renal injury.