Your browser doesn't support javascript.
loading
Induction Therapy Prior to Surgical Resection for Patients Presenting with Locally Advanced Esthesioneuroblastoma.
Miller, Kevin C; Marinelli, John P; Janus, Jeffrey R; Chintakuntlawar, Ashish V; Foote, Robert L; Link, Michael J; Choby, Garret; Van Gompel, Jamie J.
Afiliación
  • Miller KC; Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, Minnesota, United States.
  • Marinelli JP; Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, Minnesota, United States.
  • Janus JR; Department of Otolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States.
  • Chintakuntlawar AV; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, United States.
  • Foote RL; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, United States.
  • Link MJ; Department of Otolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States.
  • Choby G; Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States.
  • Van Gompel JJ; Department of Otolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States.
J Neurol Surg B Skull Base ; 82(Suppl 3): e131-e137, 2021 Jul.
Article en En | MEDLINE | ID: mdl-34306928
Esthesioneuroblastoma (ENB) is a rare olfactory malignancy that can present with locally advanced disease. At our institution, patients with ENB in whom the treating surgeon believes that a margin-negative resection is initially not achievable are selected to undergo induction with chemotherapy with or without radiotherapy prior to surgery. In a retrospective review of 61 patient records, we identified six patients (10%) treated with this approach. Five of six patients (83%) went on to definitive surgery. Prior to surgery, three of five patients (60%) had a partial response after induction therapy, whereas two of five (40%) had stable disease. Microscopically margin-negative resection was achieved in four of five (80%) of the patients who went on to surgery, while one patient had negative margins on frozen section but microscopically positive margins on permanent section. Three of five patients (60%) recurred after surgery; two of these patients died with recurrent/metastatic ENB. In summary, induction therapy may facilitate margin-negative resection in locally advanced ENB. Given the apparent sensitivity of ENB to chemotherapy and radiotherapy, future prospective studies should investigate the optimal multidisciplinary approach to improve long-term survival in this rare disease.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies Idioma: En Revista: J Neurol Surg B Skull Base Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies Idioma: En Revista: J Neurol Surg B Skull Base Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania