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Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth.
Finch, Sarah L; Rosenberg, Alan M; Kusalik, Anthony J; Maleki, Farhad; Rezaei, Elham; Baxter-Jones, Adam; Benseler, Susanne; Boire, Gilles; Cabral, David; Campillo, Sarah; Chédeville, Gaëlle; Chetaille, Anne-Laure; Dancey, Paul; Duffy, Ciaran; Duffy, Karen Watanabe; Guzman, Jaime; Houghton, Kristin; Huber, Adam M; Jurencak, Roman; Lang, Bianca; Laxer, Ron M; Morishita, Kimberly; Oen, Kiem G; Petty, Ross E; Ramsey, Suzanne E; Roth, Johannes; Schneider, Rayfel; Scuccimarri, Rosie; Stringer, Elizabeth; Tse, Shirley M L; Tucker, Lori B; Turvey, Stuart E; Szafron, Michael; Whiting, Susan; Yeung, Rae Sm; Vatanparast, Hassan.
Afiliación
  • Finch SL; University of Saskatchewan, Saskatoon, Canada; University of Prince Edward Island, Charlottetown, Canada.
  • Rosenberg AM; University of Saskatchewan, Saskatoon, Canada. Electronic address: alan.rosenberg@usask.ca.
  • Kusalik AJ; University of Saskatchewan, Saskatoon, Canada.
  • Maleki F; University of Saskatchewan, Saskatoon, Canada.
  • Rezaei E; University of Saskatchewan, Saskatoon, Canada.
  • Baxter-Jones A; University of Saskatchewan, Saskatoon, Canada.
  • Benseler S; Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Boire G; University of Sherbrooke, Sherbrooke, Canada.
  • Cabral D; BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
  • Campillo S; McGill University Health Center, Montreal, Canada.
  • Chédeville G; McGill University Health Center, Montreal, Canada.
  • Chetaille AL; le Centre Hospitalier Universitaire de Quebec, Quebec, Canada.
  • Dancey P; Janeway Children's Health and Rehabilitation Centre, St. John's, Canada.
  • Duffy C; Children's Hospital of Eastern Ontario, Ottawa, Canada.
  • Duffy KW; Children's Hospital of Eastern Ontario, Ottawa, Canada.
  • Guzman J; BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
  • Houghton K; BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
  • Huber AM; IWK Health Centre and Dalhousie University, Halifax, Canada.
  • Jurencak R; Children's Hospital of Eastern Ontario, Ottawa, Canada.
  • Lang B; IWK Health Centre and Dalhousie University, Halifax, Canada.
  • Laxer RM; The University of Toronto and The Hospital for Sick Children, Toronto, Canada.
  • Morishita K; BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
  • Oen KG; University of Manitoba, Winnipeg, Canada.
  • Petty RE; BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
  • Ramsey SE; IWK Health Centre and Dalhousie University, Halifax, Canada.
  • Roth J; Children's Hospital of Eastern Ontario, Ottawa, Canada.
  • Schneider R; The University of Toronto and The Hospital for Sick Children, Toronto, Canada.
  • Scuccimarri R; McGill University Health Center, Montreal, Canada.
  • Stringer E; IWK Health Centre and Dalhousie University, Halifax, Canada.
  • Tse SML; The University of Toronto and The Hospital for Sick Children, Toronto, Canada.
  • Tucker LB; BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
  • Turvey SE; BC Children's Hospital and The University of British Columbia, Vancouver, Canada.
  • Szafron M; University of Saskatchewan, Saskatoon, Canada.
  • Whiting S; University of Saskatchewan, Saskatoon, Canada.
  • Yeung RS; The University of Toronto and The Hospital for Sick Children, Toronto, Canada.
  • Vatanparast H; University of Saskatchewan, Saskatoon, Canada. Electronic address: vatan.h@usask.ca.
Nutr Res ; 92: 139-149, 2021 08.
Article en En | MEDLINE | ID: mdl-34311227
A number of studies have demonstrated that patients with autoimmune disease have lower levels of vitamin D prompting speculation that vitamin D might suppress inflammation and immune responses in children with juvenile idiopathic arthritis (JIA).  The objective of this study was to compare vitamin D levels in children with JIA at disease onset with healthy children. We hypothesized that children and adolescents with JIA have lower vitamin D levels than healthy children and adolescents. Data from a Canadian cohort of children with new-onset JIA (n= 164, data collection 2007-2012) were compared to Canadian Health Measures Survey (CHMS) data (n=4027, data collection 2007-2011). We compared 25-hydroxy vitamin D (25(OH)D) concentrations with measures of inflammation, vitamin D supplement use, milk intake, and season of birth. Mean 25(OH)D level was significantly higher in patients with JIA (79 ± 3.1 nmol/L) than in healthy controls (68 ± 1.8 nmol/L P <.05). Patients with JIA more often used vitamin D containing supplements (50% vs. 7%; P <.05). The prevalence of 25(OH)D deficiency (<30 nmol/L) was 6% for both groups. Children with JIA with 25(OH)D deficiency or insufficiency (<50 nmol/L) had higher C-reactive protein levels. Children with JIA were more often born in the fall and winter compared to healthy children. In contrast to earlier studies, we found vitamin D levels in Canadian children with JIA were higher compared to healthy children and associated with more frequent use of vitamin D supplements. Among children with JIA, low vitamin D levels were associated with indicators of greater inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Juvenil / Estaciones del Año / Vitamina D / Deficiencia de Vitamina D / Suplementos Dietéticos / Parto / Inflamación Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies Límite: Animals / Child / Child, preschool / Female / Humans / Male / Newborn País/Región como asunto: America do norte Idioma: En Revista: Nutr Res Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Juvenil / Estaciones del Año / Vitamina D / Deficiencia de Vitamina D / Suplementos Dietéticos / Parto / Inflamación Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies Límite: Animals / Child / Child, preschool / Female / Humans / Male / Newborn País/Región como asunto: America do norte Idioma: En Revista: Nutr Res Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos