Quality by design (QbD) optimization of diazepam-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery: Toxicological effect of surface charge on human neuronal cells.

Costa, C P; Cunha, S; Moreira, J N; Silva, R; Gil-Martins, E; Silva, V; Azevedo, L; Peixoto, A F; Sousa Lobo, J M; Silva, A C

Costa, C P; Cunha, S; Moreira, J N; Silva, R; Gil-Martins, E; Silva, V; Azevedo, L; Peixoto, A F; Sousa Lobo, J M; Silva, A C.

Afiliación

Costa CP; UCIBIO/REQUIMTE, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Cunha S; UCIBIO/REQUIMTE, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Moreira JN; CNC - Center for Neuroscience and Cell Biology, Center for Innovative Biomedicine and Biotechnology (CIBB), Faculty of Medicine (Pólo I), University of Coimbra, 3004-531 Coimbra, Portugal; UC - University of Coimbra, CIBB, Faculty of Pharmacy, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 300
Silva R; UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, Porto University, Porto, Portugal.
Gil-Martins E; UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, Porto University, Porto, Portugal.
Silva V; UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, Porto University, Porto, Portugal.
Azevedo L; UCIBIO/REQUIMTE, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Peixoto AF; LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.
Sousa Lobo JM; UCIBIO/REQUIMTE, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Silva AC; UCIBIO/REQUIMTE, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal; FP-ENAS (UFP Energy, Environment and Health Research Unit), CEBIMED (Biomedical Research Centre), Faculty of Health Sciences, University

Int J Pharm ; 607: 120933, 2021 Sep 25.

Article en En | MEDLINE | ID: mdl-34324988

Asunto(s)

Diazepam; Nanoestructuras; Encéfalo; Diazepam/toxicidad; Portadores de Fármacos; Humanos; Lípidos; Nanoestructuras/toxicidad; Tamaño de la Partícula

Palabras clave

Diazepam; Nanostructured lipid carriers (NLC); Neuronal cells; Nose-to-brain delivery; Quality by design (QbD)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanoestructuras / Diazepam Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Pharm Año: 2021 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Países Bajos

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