Risk of female-specific cancers according to obesity and menopausal status in 2â¢7 million Korean women: Similar trends between Korean and Western women.
Lancet Reg Health West Pac
; 11: 100146, 2021 Jun.
Article
en En
| MEDLINE
| ID: mdl-34327357
ABSTRACT
BACKGROUND:
Studies examining the relationship between obesity and female-specific cancers have been mainly conducted in Western populations. We aimed to investigate the risk of female-specific cancers according to obesity and menopausal status using a nationwide cohort in Korea.METHODS:
We identified 2,708,938 women from the National Health Insurance Service cohort, and obtained baseline body mass index (BMI), waist circumference (WC), and other healthcare data, measured and collected during a health examinations and cancer-screening survey. By setting a normal weight/WC group (BMI, 18â¢5-22â¢9 kg/m2 or WC, 80â¢0-84â¢9 cm) as the reference, we conducted multivariate analyses using the Cox proportional hazard model to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (95% CIs) for each cancer.FINDINGS:
The total follow-up duration was 22389854â¢63 person-years. In post-menopausal women, the risk of breast, endometrial, and ovarian cancers significantly increased as the BMI classification level increased from normal to class II obesity (aHRs [95% CIs], 1â¢49 [1â¢38-1.61], 2â¢11 [1â¢81-2â¢46], and 1â¢38 [1â¢20-1â¢58], respectively). The risk of breast and endometrial cancers also increased as the WC classification increased from < 75â¢0 to ≥ 95â¢0 cm. With a WC of 80â¢0-84â¢9 cm as the reference, the lowest risk of breast and endometrial cancers was observed in WC < 75â¢0 cm (aHRs [95% CIs], 0â¢85 [0â¢81-0â¢89] and 0â¢75 [0â¢67-0â¢84], respectively) while the highest risk was observed in WC ≥ 95â¢0 cm (aHRs [95% CIs], 1â¢19 [1â¢10-1â¢29] and 1â¢56 [1â¢33-1â¢82], respectively). In pre-menopausal women, the risk of breast cancer significantly decreased in those with class I and II obesity compared to those with normal BMI (aHRs [95% CIs], 0â¢96 [0â¢92-0â¢999] and 0â¢89 [0â¢81-0â¢97], respectively), whereas the trends of endometrial and ovarian cancer incidence in pre-menopausal women were similar to those observed in post-menopausal women. For cervical cancer, only class II obesity was significantly associated with increased risks in both post-menopausal and pre-menopausal women (aHRs [95% CIs], 1â¢18 [1â¢01-1â¢39] and 1â¢27 [1â¢02-1â¢57], respectively).INTERPRETATION:
In this large population-based cohort study in Korean women, we observed that the impact of obesity on the development of female-specific cancers differs according to the malignancy type and menopausal status. Similar trends were observed between Korean and Western women.FUNDING:
The Korea Health Industry Development Institute (no. HI16C2037).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Lancet Reg Health West Pac
Año:
2021
Tipo del documento:
Article