Blood lipid profile changes in type 2 diabetic rats after tail suspension and reloading.
Lipids Health Dis
; 20(1): 84, 2021 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-34334135
ABSTRACT
PURPOSE:
The effects of the tail suspension and reloading on the protein and lipid metabolism in muscle and blood in type 2 diabetes mellitus (T2DM) are unclear. This study evaluated the hypothesis that skeletal muscle catabolism is greater in T2DM than in non-diabetes mellitus (non-DM) rats and that the activity-dependent changes in the intramuscular lipid accumulation and blood lipid profile are poorer in T2DM than in non-DM rats.METHODS:
T2DM and non-DM rats were suspended for two weeks followed by reloading for two weeks. The muscle and blood were then examined.RESULTS:
In contrast to our hypothesis, there was no marked difference between the T2DM and non-DM groups in terms of the skeletal muscle catabolism and activity-dependent changes in intramuscular lipid accumulation. However, the blood lipid profile increased in the T2DM group compared to the non-DM group. One interesting finding in this study was the decrease in non-high-density lipoprotein (non-HDL) cholesterol levels after one week of reloading followed by a significant increase in the non-HDL cholesterol levels after two weeks of reloading in the T2DM group.CONCLUSION:
These results suggest that a dramatic increase in activity after a period of inactivity may rapidly improve the blood lipid profile in T2DM rats.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Suspensión Trasera
/
Diabetes Mellitus Tipo 2
/
Lípidos
Límite:
Animals
Idioma:
En
Revista:
Lipids Health Dis
Asunto de la revista:
BIOQUIMICA
/
METABOLISMO
Año:
2021
Tipo del documento:
Article
País de afiliación:
Japón