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A curated dataset of modern and ancient high-coverage shotgun human genomes.
Maisano Delser, Pierpaolo; Jones, Eppie R; Hovhannisyan, Anahit; Cassidy, Lara; Pinhasi, Ron; Manica, Andrea.
Afiliación
  • Maisano Delser P; Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK. pm604@cam.ac.uk.
  • Jones ER; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, 2, Ireland. pm604@cam.ac.uk.
  • Hovhannisyan A; Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK.
  • Cassidy L; Genomics Medicine Ireland, Dublin, Ireland.
  • Pinhasi R; Institute of Molecular Biology, National Academy of Sciences, 7 Hasratyan Street, 0014, Yerevan, Armenia.
  • Manica A; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, 2, Ireland.
Sci Data ; 8(1): 202, 2021 08 04.
Article en En | MEDLINE | ID: mdl-34349118
Over the last few years, genome-wide data for a large number of ancient human samples have been collected. Whilst datasets of captured SNPs have been collated, high coverage shotgun genomes (which are relatively few but allow certain types of analyses not possible with ascertained captured SNPs) have to be reprocessed by individual groups from raw reads. This task is computationally intensive. Here, we release a dataset including 35 whole-genome sequenced samples, previously published and distributed worldwide, together with the genetic pipeline used to process them. The dataset contains 72,041,355 sites called across 19 ancient and 16 modern individuals and includes sequence data from four previously published ancient samples which we sequenced to higher coverage (10-18x). Such a resource will allow researchers to analyse their new samples with the same genetic pipeline and directly compare them to the reference dataset without re-processing published samples. Moreover, this dataset can be easily expanded to increase the sample distribution both across time and space.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma Humano / Secuenciación Completa del Genoma Límite: Humans Idioma: En Revista: Sci Data Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma Humano / Secuenciación Completa del Genoma Límite: Humans Idioma: En Revista: Sci Data Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido