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Aberrant activation of the mentalizing brain system during eye gaze discrimination in bipolar disorder.
Tso, Ivy F; Burton, Cynthia Z; Lasagna, Carly A; Rutherford, Saige; Yao, Beier; Peltier, Scott J; Johnson, Timothy D; McInnis, Melvin G; Taylor, Stephan F.
Afiliación
  • Tso IF; Department of Psychiatry, University of Michigan, Ann Arbor, United States. Electronic address: ivytso@umich.edu.
  • Burton CZ; Department of Psychiatry, University of Michigan, Ann Arbor, United States.
  • Lasagna CA; Department of Psychiatry, University of Michigan, Ann Arbor, United States.
  • Rutherford S; Department of Psychiatry, University of Michigan, Ann Arbor, United States; Radboud University Medical Centre, Nijmegen, the Netherlands.
  • Yao B; Department of Psychology, Michigan State University, United States.
  • Peltier SJ; Functional MRI Laboratory, University of Michigan, Ann Arbor, United States; Department of Biomedical Engineering, University of Michigan, Ann Arbor, United States.
  • Johnson TD; Department of Biostatistics, University of Michigan, Ann Arbor, United States.
  • McInnis MG; Department of Psychiatry, University of Michigan, Ann Arbor, United States.
  • Taylor SF; Department of Psychiatry, University of Michigan, Ann Arbor, United States.
Psychiatry Res Neuroimaging ; 315: 111340, 2021 09 30.
Article en En | MEDLINE | ID: mdl-34358977
ABSTRACT
Bipolar disorder (BD) is associated with a range of social cognitive deficits. This study investigated the functioning of the mentalizing brain system in BD probed by an eye gaze perception task during fMRI. Compared with healthy controls (n = 21), BD participants (n = 14) showed reduced preferential activation for self-directed gaze discrimination in the medial prefrontal cortex (mPFC) and temporo-parietal junction (TPJ), which was associated with poorer cognition/social cognition. Aberrant functions of the mentalizing system should be further investigated as marker of social dysfunction and treatment targets.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Mentalización Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2021 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Mentalización Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2021 Tipo del documento: Article