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Immunophenotypic shifts during minimal residual evaluation in a case of leukemic form of anaplastic large cell lymphoma ALK.
Canellas, Maria Clara; Bruno-Riscarolli, Enrico; Ferreira-Facio, Cristiane S; Lopes-Alves, Daiana V; Botafogo, Vitor D; Sutter, Deborah; Pontes, Roberia M; Land, Marcelo G P; Bedran Milito, Cristiane; da Costa, Elaine Sobral.
Afiliación
  • Canellas MC; Martagão Gesteira Pediatric Institute - Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Bruno-Riscarolli E; Martagão Gesteira Pediatric Institute - Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Ferreira-Facio CS; Martagão Gesteira Pediatric Institute - Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Lopes-Alves DV; Martagão Gesteira Pediatric Institute - Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Botafogo VD; Martagão Gesteira Pediatric Institute - Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Sutter D; Martagão Gesteira Pediatric Institute - Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Pontes RM; Martagão Gesteira Pediatric Institute - Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Land MGP; Martagão Gesteira Pediatric Institute - Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Bedran Milito C; Department of Pediatrics, Faculty of Medicine - Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • da Costa ES; Department of Pathology, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Cancer Rep (Hoboken) ; 5(7): e1526, 2022 07.
Article en En | MEDLINE | ID: mdl-34382381
ABSTRACT

BACKGROUND:

This study aims to describe immunophenotypic explorations at diagnosis and follow up of a pediatric patient with leukemic phase of ALK+ anaplastic large cell lymphoma (ALCL) by multiparametric flow cytometry (MFC). CASE An 8-color MFC combination of antibodies allowed to identify neoplastic cells in concentrations until 0.02% during minimal residual disease (MRD) monitoring. Immunophenotypic shifts occurred in key markers as CD30, CD7, CD2, and CD5, however neoplastic cells were clearly discriminated from normal populations.

CONCLUSION:

MFC can be a useful tool for ALCL diagnosis and MRD monitoring and may support therapeutic decisions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma Anaplásico de Células Grandes Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Child / Humans Idioma: En Revista: Cancer Rep (Hoboken) Año: 2022 Tipo del documento: Article País de afiliación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma Anaplásico de Células Grandes Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Child / Humans Idioma: En Revista: Cancer Rep (Hoboken) Año: 2022 Tipo del documento: Article País de afiliación: Brasil