Determinants of response and mechanisms of resistance of CAR T-cell therapy in multiple myeloma.
Blood Cancer Discov
; 2(4): 302-318, 2021 07.
Article
en En
| MEDLINE
| ID: mdl-34386775
ABSTRACT
BCMA-specific CAR T-cells have substantial therapeutic potential in multiple myeloma (MM), but most patients eventually relapse. Determinants of response and mechanisms of resistance are most likely multifactorial and include MM-related factors, premanufacturing T-cell characteristics, CAR T-cell-related features, and several components of the immunosuppressive microenvironment. Efforts to improve the potency and safety of CAR T-cell therapy include optimizing CAR design, combinatorial approaches to enhance persistence and activity, treatment of less heavily pretreated patients, and dual-antigen targeting to prevent antigen escape. We expect that these rationally designed strategies will contribute to further improvement in the clinical outcome of MM patients.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores Quiméricos de Antígenos
/
Mieloma Múltiple
Límite:
Humans
Idioma:
En
Revista:
Blood Cancer Discov
Año:
2021
Tipo del documento:
Article
País de afiliación:
Países Bajos